MCCC1

  • Official Full Name

    methylcrotonoyl-CoA carboxylase 1 (alpha)

  • Overview

    This gene encodes the large subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism.

  • Synonyms

    MCCC1;methylcrotonoyl-CoA carboxylase 1 (alpha);methylcrotonoyl Coenzyme A carboxylase 1 (alpha);methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial;MCCA;3-methylcrotonyl-CoA carboxylase 1;MCCase subunit alpha;OTTHUMP00000212827;OTTHUMP00000212828;OTTHUMP00000212829;OTTHUMP00000212832;methylcrotonoyl-Coenzyme A carboxylase 1 (alpha);3-methylcroto;MCC-B

Recombinant Proteins

  • Chicken
  • Rat
  • Zebrafish
  • Human
  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • His&T7
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
MCCC1-1689C Recombinant Chicken MCCC1 Mammalian Cells Chicken His
MCCC1-3614R Recombinant Rat MCCC1 Protein Mammalian Cells Rat His
MCCC1-4019Z Recombinant Zebrafish MCCC1 Mammalian Cells Zebrafish His
MCCC1-401H Recombinant Human MCCC1 Protein, His-tagged E.coli Human His
Mccc1-8173M Recombinant Mouse Mccc1 protein, His & T7-tagged E.coli Mouse His&T7 Phe484~Lys717
MCCC1-9624M Recombinant Mouse MCCC1 Protein Mammalian Cells Mouse His
MCCC1-4429HCL Recombinant Human MCCC1 293 Cell Lysate HEK293 Human Non
MCCC1-2429H Recombinant Human MCCC1 Protein, His-tagged E.coli Human His Ala512-Glu725
MCCC1-3270R Recombinant Rat MCCC1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
MCCC1-3270R-B Recombinant Rat MCCC1 Protein Pre-coupled Magnetic Beads HEK293 Rat
MCCC1-5405M Recombinant Mouse MCCC1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
MCCC1-5405M-B Recombinant Mouse MCCC1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    MCCC1 involved in several pathways and played different roles in them. We selected most pathways MCCC1 participated on our site, such as Valine, leucine and isoleucine degradation,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCCC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Valine, leucine and isoleucine degradation HMGCL,OXCT1,ALDH7A1,ACAA1A,AOX4,HMGCS1,HADH,AOX1,MUT,IL4I1
    Metabolic pathways PDHX,OGDHL,PRIM2,ATP6V0E1,CYP3A41B,PLA2G4D,ST3GAL4,GNSA,G6PDX,SDSL

    Protein Function

    MCCC1 has several biochemical functions, for example, ATP binding,biotin binding,biotin carboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MCCC1 itself. We selected most functions MCCC1 had, and list some proteins which have the same functions with MCCC1. You can find most of the proteins on our site.

    Function Related Protein
    biotin carboxylase activity PC,PCXB,PCCA,ACACA,PCXA,ACACB
    methylcrotonoyl-CoA carboxylase activity MCCC2
    biotin binding HLCS,PC,PCXA,PCCA,PCXB,AVR2
    protein binding HEMGN,FZD6,KIFC3,HEYL,SUPT4H1,TARBP2,LGR6,STAC,SLC9A3,CDT1
    ATP binding PLK3,P2RX4A,UBE2M,BMPR1AA,DHX33,ATP5B,AKT3A,CDC42BPA,UCK2,KDR
    metal ion binding ERI3,KAT8,GLI2B,RBM4B,RASAL1,COPS5,ZNF521,TAX1BP1,ZNF691,COX5A

    Interacting Protein

    MCCC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCCC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCCC1.

    US11;IFIT1;PPP2R2B;STK4;SIRT4

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