MBD2
-
Official Full Name
methyl-CpG binding domain protein 2 -
Overview
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
MBD2;methyl-CpG binding domain protein 2;methyl-CpG-binding domain protein 2;demethylase;DMTase;NY-CO-41;DKFZp586O0821
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MBD2-12037Z | Recombinant Zebrafish MBD2 | Mammalian Cell | Zebrafish | His |
|
|
| MBD2-1893C | Recombinant Chicken MBD2 | Mammalian Cell | Chicken | His |
|
|
| Kit-0541 | MBD2 Binding Activity/Inhibition Assay Kit | Non |
|
|||
| MBD2-405H | Recombinant Human MBD2 Protein, His-tagged | E.coli | Human | His | Glu145~Ala411 |
|
| MBD2-4938H | Recombinant Human MBD2 protein(143-411aa), His-KSI-tagged | E. coli | Human | N-His-KSI | 143-411aa |
|
| MBD2-5643H | Recombinant Human MBD2 protein, hFc-tagged | Yeast | Human | Fc | 145-411aa |
|
Involved Pathway
MBD2 involved in several pathways and played different roles in them. We selected most pathways MBD2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MBD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MBD2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MBD2 itself. We selected most functions MBD2 had, and list some proteins which have the same functions with MBD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
MBD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MBD2.
Resources
Related Services
Related Products
References
- Gopisetty, G; Xu, J; et al. Epigenetic regulation of CD133/PROM1 expression in glioma stem cells by Sp1/myc and promoter methylation. ONCOGENE 32:3119-3129(2013).
- Stefanska, B; Suderman, M; et al. Transcription onset of genes critical in liver carcinogenesis is epigenetically regulated by methylated DNA-binding protein MBD2. CARCINOGENESIS 34:2738-2749(2013).
