MASTL
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Official Full Name
microtubule associated serine/threonine kinase-like -
Overview
This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. -
Synonyms
MASTL;microtubule associated serine/threonine kinase-like;serine/threonine-protein kinase greatwall;FLJ14813;THC2;2700091H24Rik;C88295;GW;GWL;GWL_HUMAN;hGWL;MAST-L;MGC117975;microtubule associated serine/threonine kinase like;Microtubule-associated serine/threonine-protein kinase-like;RP11 85G18.2;greatwall protein kinase;GREATWALL;RP11-85G18.2
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Insect Cells
- Mammalian Cells
- HEK293
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MASTL-757H | Recombinant Human MASTL, His-tagged | E.coli | Human | His | 34-219aa | |
| MASTL-156H |
Active Recombinant Human MASTL Protein, GST-tagged
|
Insect Cells | Human | GST |
|
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| MASTL-1035Z | Recombinant Zebrafish MASTL | Mammalian Cells | Zebrafish | His |
|
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| MASTL-9582M | Recombinant Mouse MASTL Protein | Mammalian Cells | Mouse | His |
|
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| MASTL-4456HCL | Recombinant Human MASTL 293 Cell Lysate | HEK293 | Human | Non |
|
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| Mastl-3968M | Recombinant Mouse Mastl Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| MASTL-5382M | Recombinant Mouse MASTL Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| MASTL-5382M-B | Recombinant Mouse MASTL Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MASTL involved in several pathways and played different roles in them. We selected most pathways MASTL participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,M Phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with MASTL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitotic Prophase | NEK9,TMEM188,NEK6,NCAPD3,SETA,ARPP19B,ENSAA,VRK2,VRK1,PHF8 |
| M Phase | NCAPG,TMEM188,APITD1,CCDC99,NCAPG2,CENPQ,MIS12,NIPBL,CENPE,STAG2 |
| MASTL Facilitates Mitotic Progression | ENSA,ENSAA,ARPP19B,ARPP19A,ARPP19,ENSAB |
| Cell Cycle, Mitotic | NCAPG2,H3F3D,CTDNEP1A,ERCC6L,FGFR1OP,CDK7,KIF2C,DYNC1I2,DCTN1A,TCTN2 |
| Cell cycle | NCAPD3,MYCA,NSL1,CDK11A,NUPL2,AHCTF1,NDEL1B,SMAD3A,ARF1,ESCO1 |
Protein Function
MASTL has several biochemical functions, for example, ATP binding,kinase activity,protein phosphatase 2A binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MASTL itself. We selected most functions MASTL had, and list some proteins which have the same functions with MASTL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | PASK,CLK1,PHKG2,ERN2,SLC14A2,AAK1,CDK15,STK30,OBSCN,ALPK1 |
| kinase activity | CAMK1GB,PAK2A,TGFBR1A,JAK2B,PTK6B,CLK4B,LTK,SGK2A,CAMK2D2,JAK2A |
| ATP binding | TRPM4,DGKA,GRK1A,ATP13A,UBE2NA,SGK196,MYLK2,SYN1,PGS1,CAD |
| protein phosphatase 2A binding | ARPP19,MAPT,SHC1,TRP53,IGBP1,PPME1,PTPN1,PPP2R2A,PPP2R4,ENSAA |
Interacting Protein
MASTL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MASTL here. Most of them are supplied by our site. Hope this information will be useful for your research of MASTL.
Dynll1;MED26;SSFA2;TAP2;CDK18;RPS6KA1;SLC1A5;MRPL2;ACBD5;CEP85;FASTKD5;TMEM263;PLEKHA8;DERL2;EPB41L5;UBN1;TELO2
Resources
Related Services
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References
- Wang, L; Fisher, LA; et al. Monoclonal Antibodies Against Xenopus Greatwall Kinase. HYBRIDOMA 30:469-474(2011).
