MASP1
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Official Full Name
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) -
Overview
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants. -
Synonyms
MASP1;mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor);CRARF, mannan binding lectin serine protease 1 (C4/C2 activating component of Ra reactive factor) , PRSS5;mannan-binding lectin serine protease 1;MASP;Complement factor MASP-3;Complement factor MASP3;Complement-activating component of Ra-reactive factor;CRARF;Mannose binding lectin associated serine protease 1;Mannose binding protein associated serine protease;Mannose-binding lectin-associated serine protease 1;Mannose-binding lectin-associated serine protease-1;PRSS 5;Ra-reactive factor serine protease p100;RaRF;Serine protease 5;OTTHUMP00000209926;OTTHUMP00000209927;OTTHUMP00000209928;OTTHUMP00000209929;OTTHUMP00000209930;mannose-binding protein-associated se;MAP1;MASP3;MAp44;PRSS5;CRARF1
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- HEK293
- E.coli
- Mammalian Cells
- Wheat Germ
- Yeast
- His
- GST
- Non
- DDK&Myc
- Avi&Fc&His
- His&SUMO
- Flag
Involved Pathway
MASP1 involved in several pathways and played different roles in them. We selected most pathways MASP1 participated on our site, such as Complement and coagulation cascades,Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with MASP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Staphylococcus aureus infection | FCGR3A,Itgam&Itgb2,Hc,C1QB,FCGR3,MBL2,FCGR3B,FPR2,CFB,GM5077 |
| Complement and coagulation cascades | SERPINA1A,C8G,CR1,VWF,CFH,C3AR1,F2,BDKRB1,C1R,F5 |
Protein Function
MASP1 has several biochemical functions, for example, calcium ion binding,calcium-dependent protein binding,peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MASP1 itself. We selected most functions MASP1 had, and list some proteins which have the same functions with MASP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptidase activity | Ren1,PM20D1.2,PPPDE1,FAM108A1,GM5077,Acr,CTSBA,USP43,KLK1B11,TMPRSS13A |
| calcium ion binding | SYT7,EFEMP2,EYS,SPOCK1,PCDHB5,PCDHGC3,CDH24,PROZ,NOTCH4,VCAN |
| calcium-dependent protein binding | CALM1,CD209A,ANXA1,C9orf9,S100A11,MASP2,ANXA11,SEC31A,MYO1D,SELP |
| serine-type endopeptidase activity | GM5077,HTRA4,PIK3IP1,KLK1B4,F12,CELA2B,CTRL,KLK15,F11,PRSS41 |
| protein binding | CLCNKB,ARL11,DNAI1,TCL1A,WSB1,ITPKB,MAPK8IP2,MTA1,APOA4,EIF2S2 |
| protein homodimerization activity | PVALB,UGT1A9,CADM2,CBX5,DARS2,TPR,FZD9,ATF3,CBS,ACVR1 |
Interacting Protein
MASP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MASP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MASP1.
NCK2;NUDT21;H2AFX;GADD45A;GSK3B;RPS6KA3;MAPK8IP2;MAPK6;UFD1L;RPS6KA6;ERBB3;CDK7;CDC37;AP2M1;ERRFI1
Resources
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References
- Thiel, S; Jensen, L; et al. Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 169:38-48(2012).
- Skjoedt, MO; Hummelshoj, T; et al. Serum concentration and interaction properties of MBL/ficolin associated protein-1. IMMUNOBIOLOGY 216:625-632(2011).
