MARK4
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Official Full Name
MAP/microtubule affinity-regulating kinase 4 -
Overview
Microtubule associated proteins regulate the stability of microtubules and control processes such as cell polarity/differentiation, neurite outgrowth, cell division and organelle trafficking. The MARK (MAP/microtubule affinity-regulating kinases) family ( -
Synonyms
MARK4;MAP/microtubule affinity-regulating kinase 4;MAP/microtubule affinity regulating kinase like 1 , MARKL1;FLJ90097;KIAA1860;Nbla00650;MARK4 serine/threonine protein kinase;MAP/microtubule affinity-regulating kinase like 1;MARK4L;MARK4S;MARKL
Recombinant Proteins
- Human
- Mouse
- Sf9 Cells
- Mammalian Cells
- HEK293
- E.coli
- Sf21 Cells
- GST
- Non
- His
- Avi&Fc&His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MARK4-1058H | Recombinant Human MAP/Microtubule Affinity-Regulating Kinase 4, GST-tagged | Sf9 Cells | Human | GST |
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| MARK4-29129TH | Recombinant Human MARK4 | Sf9 Cells | Human | Non | 752 amino acids |
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| MARK4-9570M | Recombinant Mouse MARK4 Protein | Mammalian Cells | Mouse | His |
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| MARK4-4464HCL | Recombinant Human MARK4 293 Cell Lysate | HEK293 | Human | Non |
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| MARK4-1198H | Recombinant Human MARK4 Protein (N44-K370), Tag Free | E.coli | Human | Non | N44-K370 |
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| MARK4-1199H | Recombinant Human MARK4 Protein (N44-K370), His tagged | E.coli | Human | His | N44-K370 |
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| MARK4-1361HF | Active Recombinant Full Length Human MARK4 Protein, GST-tagged | Sf21 Cells | Human | GST | Full L. 1-688 |
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| MARK4-5375M | Recombinant Mouse MARK4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| MARK4-5375M-B | Recombinant Mouse MARK4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MARK4 involved in several pathways and played different roles in them. We selected most pathways MARK4 participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,LKB1 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with MARK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Organelle biogenesis and maintenance | MRRF,MRPS27,MRPL37,MRPS28,MRPL46,KIFAP3B,MRPL48,ATAT1,MRPL39,MRPL54 |
| Anchoring of the basal body to the plasma membrane | CENPJ,TUBB4A,ODF2,TUBB4B,TCTN1,SCLT1,DCTN1A,SDCCAG8,RPGRIP1L,DYNC1I2 |
| Assembly of the primary cilium | KIFAP3B,CCT4,ARF4,MAPRE1A,EXOC5,CCDC41,MKS1,TUBB4A,CYS1,TCP1 |
| LKB1 signaling events | CDC37,STK11IP,CTSD,MAP2,SIK3,MARK2 |
Protein Function
MARK4 has several biochemical functions, for example, ATP binding,gamma-tubulin binding,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MARK4 itself. We selected most functions MARK4 had, and list some proteins which have the same functions with MARK4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin binding | PARK2,FAN1,TRP53INP2,UBE2NB,SPRTN,UCHL3,USP25,TOP2A,NBR1,IWS1 |
| microtubule binding | GLI1,MAPT,KIF3A,MAPRE1A,KIF3C,ARL3,NME8,TRAF3IP1,DPYSL5,KIF20B |
| protein serine/threonine kinase activity | RIPK1,WNK1,MKNK2,SNRK,PRKAA2,STK4,CDC42BPA,PRKY,NEK1,TAF1 |
| protein binding | F11,MVK,SLC26A6,AGO1,HSPB1,IFT46,AP4M1,LEPROT,WBP1,TMEM51 |
| ATP binding | GLULB,AASDH,CMPK2,RBM4.3,PIK3CA,UBE2D4,VMHCL,TLK1A,EP400,PRKACAA |
| gamma-tubulin binding | TUBGCP3,CEP57L1,SPATC1,B9D2,NDRG1,WASH,FEZ1,PIFO,OFD1,TUBGCP5 |
| tau-protein kinase activity | PRKAA1,GSK3A,GSK3B,CDK5,MARK2,MARK1,PHKG2,PHKG1,CSNK1D |
Interacting Protein
MARK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MARK4.
YWHAH;TUBG1;STK11;PRKCI;CDC42;PNMA1;PRNP;MAPT
MARK4 Related Signal Pathway
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References
- Gu, GJ; Lund, H; et al. Role of Individual MARK Isoforms in Phosphorylation of Tau at Ser(262) in Alzheimer's Disease. NEUROMOLECULAR MEDICINE 15:458-469(2013).
- Houde, VP; Ritorto, MS; et al. Investigation of LKB1 Ser(431) phosphorylation and Cys(433) farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity. BIOCHEMICAL JOURNAL 458:41-56(2014).
- Magnani, I; Novielli, C; et al. Multiple localization of endogenous MARK4L protein in human glioma. CELLULAR ONCOLOGY 31:357-370(2009).
- Moroni, RF; De Biasi, S; et al. Distinct expression pattern of microtubule-associated protein/microtubule affinity-regulating kinase 4 in differentiated neurons. NEUROSCIENCE 143:83-94(2006).
