MARCH9
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Official Full Name
membrane-associated ring finger (C3HC4) 9 -
Overview
MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]). -
Synonyms
MARCH9;membrane-associated ring finger (C3HC4) 9;E3 ubiquitin-protein ligase MARCH9;FLJ36578;RNF179;FLJ36578;BC019560;E3 ubiquitin protein ligase MARCH9;MARCH IX;Membrane associated RING CH protein IX;membrane associated ring finger (C3HC4) 9;Membrane associated RING finger protein 9;RING finger protein 179;RNF179;OTTHUMP00000243862;RING finger protein 179;membrane-associated RING-CH protein IX;membrane-associated RING finger protein 9;MARCH-IX
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- N-His
- His
- His&Fc&Avi
Involved Pathway
MARCH9 involved in several pathways and played different roles in them. We selected most pathways MARCH9 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MARCH9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MARCH9 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MARCH9 itself. We selected most functions MARCH9 had, and list some proteins which have the same functions with MARCH9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein-glutamic acid ligase activity | SIAH2L,HERC2,TRIM50,LTN1,UBE2IB,SHRPRBCK1R,RFWD2,TRIM71,TRIM41,UBR1 |
| ribosomal S6-glutamic acid ligase activity | MARCH6,RNF149,RAG1,ITCHA,MYLIPA,ZNRF3,RNF187,TMEM129,MUL1A,NEURL1B |
| coenzyme F420-2 alpha-glutamyl ligase activity | RC3H2,LTN1,SHRPRBCK1R,SIAH1A,MYLIPA,RNF187,G2E3,UBE2IA,RNF180,MGRN1A |
| coenzyme F420-0 gamma-glutamyl ligase activity | RNF169,ARIH1L,RFWD2,TRIM50,RNF144AA,ZNRF3,MARCH5L,SIAH1A,UBR1,G2E3 |
| tubulin-glycine ligase activity | SIAH1A,G2E3,RFWD2,MUL1A,RAG1,MARCH4,ARIH1L,RNF144AB,NEURL3,TRIM71 |
| protein-glycine ligase activity | MYLIPB,SHRPRBCK1R,RC3H2,UBE2IA,HERC2,G2E3,TTLL3,SIAH1A,NEURL3,ITCHA |
| tubulin-glutamic acid ligase activity | LTN1,NEURL3,RNF180,MARCH6,RFWD2,SIAH2L,MARCH11,MARCH4,HECW2,RNF169 |
| ligase activity | RNF144AB,UBE2KA,TTLL11,MYLIPB,TRIM23,NAPRT,FPGS,MID1,TRAF7,UBE2IA |
| zinc ion binding | ADAM5,FANCL,MPI,TRIM17,MSL2,ZNRF1,PHRF1,BSPRY,LIMS1,TRAF2 |
Interacting Protein
MARCH9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARCH9 here. Most of them are supplied by our site. Hope this information will be useful for your research of MARCH9.
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