MARCH8
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Official Full Name
membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase -
Synonyms
MARCH8;membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase;23356;ENSG00000165406;MIR;c-MIR;RNF178;MARCH-VIII;10q11.21;E3 ubiquitin-protein ligase MARCH8;E3 ubiquitin-protein ligase MARCH8;RING finger protein 178;membrane-associated RING-CH protein VIII;membrane-associated RING finger protein 8;c-mir, cellular modulator of immune recognition;cellular modulator of immune recognition (c-MIR)
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- Xenopus laevis
- Bovine
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
Involved Pathway
MARCH8 involved in several pathways and played different roles in them. We selected most pathways MARCH8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MARCH8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MARCH8 has several biochemical functions, for example, MHC class II protein binding,ligase activity,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MARCH8 itself. We selected most functions MARCH8 had, and list some proteins which have the same functions with MARCH8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase activity | RNF13,TRIM2,PPIL2,RNF6,SIAH1A,HERC6,BTRC,MSL2B,CBLC,CDC34B |
| ligase activity | RNF149,TRIM33,PPIL2,UHRF1,CBL,UBE2CBP,SIAH2,ARIH2,TRIM38,RNF213 |
| zinc ion binding | TRIM13,HNF4A,RTN4IP1,KDM5BA,RNF10,CHD4A,BMI1,ZCCHC10,GATAD2B,RNF4 |
| MHC class II protein binding | CD74B,KRT17,LAG3,CD4,CD74,CD74A |
| ubiquitin-protein transferase activity | MALT1,RNF144AB,UBR3,FBXO3,RNF139,FBXO30B,BIRC5B,SIAH1,CDC23,DTX3L |
Interacting Protein
MARCH8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARCH8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MARCH8.
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References
- Funakoshi, Y; Chou, MM; et al. TRE17/USP6 regulates ubiquitylation and trafficking of cargo proteins that enter cells by clathrin-independent endocytosis. JOURNAL OF CELL SCIENCE 127:4750-4761(2014).
- Kim, MH; Rebbert, ML; et al. Cell Adhesion in Zebrafish Embryos Is Modulated by March8. PLOS ONE 9:-(2014).
