MAPKAP1
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Official Full Name
mitogen-activated protein kinase associated protein 1 -
Overview
SIN1 encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Recent studies have shown that it is identical to MIP1 for MEKK2 interacting protein 1. MAPKAP1 has also been shown to play a role in the TOR signa -
Synonyms
MAPKAP1;mitogen-activated protein kinase associated protein 1;target of rapamycin complex 2 subunit MAPKAP1;MGC2745;MIP1;SIN1;stress activated protein kinase interacting 1;mSIN1;TORC2 subunit MAPKAP1;ras inhibitor MGC2745;SAPK-interacting protei
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- His
- Non
- Flag
- His&Fc&Avi
- His&GST
- His&SUMO
- Myc&DDK
Involved Pathway
MAPKAP1 involved in several pathways and played different roles in them. We selected most pathways MAPKAP1 participated on our site, such as Adaptive Immune System,CD28 co-stimulation,CD28 dependent PI3K/Akt signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPKAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| CD28 dependent PI3K/Akt signaling | THEM4,PDPK1A,MAP3K8 |
| Costimulation by the CD28 family | BTLA,PDPK1A,HLA-DQB2,CSK,CTLA4,MAP3K8,THEM4 |
| CXCR4-mediated signaling events | JAK2,BLK,CFL1,CRK,PAG1,CSK,ARR3,GNA13,GNB2L1,ADRBK1 |
| CXCR3-mediated signaling events | DNM1,CXCL13 |
| Adaptive Immune System | AKT3,KIF2A,CTSD,OSBPL1A,AF251705,FBXO27,CD300E,KIF18A,DNM2,NRG3 |
| CD28 co-stimulation | MAP3K8,THEM4,PDPK1A |
Protein Function
MAPKAP1 has several biochemical functions, for example, Ras GTPase binding,phosphatidic acid binding,phosphatidylinositol-3,4,5-trisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPKAP1 itself. We selected most functions MAPKAP1 had, and list some proteins which have the same functions with MAPKAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidic acid binding | UQCC3,RAPGEF6,PACSIN2,COMMD1,JPH2,NRGN,PLCD1,SESTD1,MARK1,MICALL1 |
| Ras GTPase binding | PLCE1,RAPGEF4,RAPGEF6,MLLT4,RGL3,RASGRP3,SPHK2,MAP2K1,RAP1A,RIN1 |
| phosphatidylinositol-3,5-bisphosphate binding | SESTD1,FAM21C,WDR45,JPH2,SH3PXD2B,CLVS1,WDR45B,KIF16B,RS1,PHLDA3 |
| phosphatidylinositol-3,4-bisphosphate binding | GAB2,SESTD1,ADAP2,NCF1,ARAP3,PLEKHA1,COMMD1,PHLDA3,D6WSU116E,ANXA8 |
| protein kinase binding | HIF1A,RPS6,HDAC7,GCSAM,ADIPOR1,EPHA1,CDC25C,LIPE,CAMK2N2,CDK5RAP1 |
| protein binding | SLC6A18,SMAD3A,MSRB3,ARMCX5-GPRASP2,NME4,ZFYVE1,RRP7A,C19orf40,RALYL,LCMT1 |
| phosphatidylinositol-4,5-bisphosphate binding | ACTN2,KRIT1,FAM21C,FCHO2,SNX20,ANXA2,COMMD1,LDLRAP1,CHMP3,PFN1 |
| phosphatidylinositol-3,4,5-trisphosphate binding | ARHGAP9,FERMT2,ARAP1,GBF1,ANXA8,NRGN,INPPL1,D6WSU116E,DAPP1,ASAP1 |
Interacting Protein
MAPKAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPKAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPKAP1.
MTOR;RICTOR
MAPKAP1 Related Signal Pathway
Resources
Research Area
Phospholipases, Small GTPases, and Other Molecules in the Akt PathwaymTOR Complexes
PI3K Pathway
Related Services
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References
- Hu-Lieskovan, S; Mok, S; et al. Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma. SCIENCE TRANSLATIONAL MEDICINE 7:-(2015).
- Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
