MAPK8IP2
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Official Full Name
mitogen-activated protein kinase 8 interacting protein 2 -
Overview
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. -
Synonyms
MAPK8IP2;mitogen-activated protein kinase 8 interacting protein 2;PRKM8 interacting protein like , PRKM8IPL;C-Jun-amino-terminal kinase-interacting protein 2;IB2;islet brain 2;JIP2;JNK interacting protein 2;IB-2;JIP-2;islet-brain 2;islet-brain-
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MAPK8IP2-29843TH | Recombinant Human MAPK8IP2, His-tagged | E.coli | Human | His | 569-797 a.a. |
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| MAPK8IP2-402HCL | Recombinant Human MAPK8IP2 lysate | HEK293 | Human | Non |
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| MAPK8IP2-301565H | Recombinant Human MAPK8IP2 protein, GST-tagged | E.coli | Human | GST | Thr41-Lys135 |
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| MAPK8IP2-384H | Recombinant Human MAPK8IP2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| Mapk8ip2-3947M | Recombinant Mouse Mapk8ip2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| MAPK8IP2-6302H | Recombinant Human MAPK8IP2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
MAPK8IP2 involved in several pathways and played different roles in them. We selected most pathways MAPK8IP2 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK8IP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MAPK13,MAPK1,RAP1A,AKT3A,FGF9,FGF1B,FGF7,MAPK4,PDGFAA,TAB2 |
Protein Function
MAPK8IP2 has several biochemical functions, for example, MAP-kinase scaffold activity,beta-amyloid binding,kinesin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK8IP2 itself. We selected most functions MAPK8IP2 had, and list some proteins which have the same functions with MAPK8IP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | MLKL,USP37,BCL2L14,PPP1R15A,TTN,CCNL2,CD4,SREBF1,IBTK,TPX2 |
| protein binding | VIPR1,LPXN,PPP1R9A,KIR2DL1,TLE1,C16orf87,CNTROB,DYNLL1,EDN1,CTNNA3 |
| MAP-kinase scaffold activity | SPAG9A,CD36,DUSP19,SPAG9,JIP1,KSR1,MAPK8IP3 |
| protein complex binding | DLG4,TXN2,GRIN2A,SIX2,ING2,BAG3,LCK,VAMP2,MYC,RAP1B |
| kinesin binding | KIFAP3A,SPAG9A,KCNC1,JIP1,AP1G1,JAKMIP1,CD36,ARPC2,KIF18B,IFT88 |
| protein kinase activator activity | STRADA,WNT11,TOM1L1,GPRC5B,EPO,CAB39,PRKAG2,NCKAP1L,FGF13,NKX3-1 |
| beta-amyloid binding | APOE,CLSTN1,HSD17B10,APOA1,Apba1,TM2D1,APBB1,CD74,BCHE,ITM2C |
| structural molecule activity | CLDNJ,KRT27,LMNTD1,KRT24,CLDN7B,CLDN2,LAMA3,KRT12,LELP1,NUMA1 |
Interacting Protein
MAPK8IP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK8IP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK8IP2.
EGFR;UBD;ANGPT1;q53hf2_human;IGIP;TMEM128;C22orf39;C8orf33
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