MAP3K3

  • Official Full Name

    mitogen-activated protein kinase kinase kinase 3

  • Overview

    MAP kinase kinase kinase (MEKK3 or MAP3K3) is a serine/threonine protein kinase that activates SAPK and ERK via phosphorylation and activation of their respective MAP kinase kinases, SEK and MEK1/2 (1,2). MEKK3 also stimulates MEK5 via activation of ERK5/

  • Synonyms

    MAP3K3;mitogen-activated protein kinase kinase kinase 3;MEKK3;MAP/ERK kinase kinase 3;MAPK/ERK kinase kinase 3;MAPKKK3;MEKK 3;MEK kinase 3

Recombinant Proteins

  • Human
  • Rhesus macaque
  • E.coli
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • HEK293
  • Insect (sf21)
  • His
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
MAP3K3-2492H Recombinant Human MAP3K3 protein, His-tagged E.coli Human His 281-366 aa
MAP3K3-1259H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 3, GST-tagged Insect Cell Human GST Full L.
MAP3K3-2669R Recombinant Rhesus monkey MAP3K3 Protein, His-tagged Mammalian Cell Rhesus macaque His
MAP3K3-30192TH Recombinant Human MAP3K3 Human Non
MAP3K3-352H Recombinant Human MAP3K3, GST-tagged, Active Sf9 Insect Cell Human GST
MAP3K3-735H Recombinant Human MAP3K3 Protein, His-tagged E.coli Human His
MAP3K3-4505HCL Recombinant Human MAP3K3 293 Cell Lysate HEK293 Human Non
MAP3K3-2489R Recombinant Rhesus Macaque MAP3K3 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
MAP3K3-2489R-B Recombinant Rhesus Macaque MAP3K3 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
MAP3K3-9152HF Active Recombinant Full Length Human MAP3K3 Protein, GST-tagged Insect (sf21) Human GST Full L. 1-626

    Involved Pathway

    MAP3K3 involved in several pathways and played different roles in them. We selected most pathways MAP3K3 participated on our site, such as MAPK signaling pathway,Neurotrophin signaling pathway,GnRH signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    HTLV-I infection HLA-DRB5,RAN,H2-Q10,Adcy4,PTTG2,TNF,TBPL1,TGFBR2,HLA-DMA,HLA-DOA
    GnRH signaling pathway PRKACAA,HRAS,CAMK2G,MAPK11,RAF1A,CACNA1C,GNRHR4,GNRHR1,CAMK2G1,PLCB1
    Neurotrophin signaling pathway MAP2K1,PIK3R5,CAMK2B,MAPK10,RPS6KA6,BDNF,MAP2K7,BAX,AKT1,IRAK1
    MAPK signaling pathway GADD45B,HRAS,DUSP8A,GNG12,FGF12,JIP1,GADD45AB,CACNB2,PDGFRB,NRAS

    Protein Function

    MAP3K3 has several biochemical functions, for example, ATP binding,MAP kinase kinase kinase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K3 itself. We selected most functions MAP3K3 had, and list some proteins which have the same functions with MAP3K3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MKNK2A,SGK2,ATP2B1B,C10orf2,PLK1,CHD2,CSNK1G2,UBE2C,UCKL1,AAK1
    metal ion binding GFI1B,FTR54,POMT2,ZFP143,ROCK1,ACACB,ARSI,ZFP775,LMAN2L,ALOX5B.2
    protein kinase activity GRK1B,GM7168,MKNK2A,STK25B,ARAF,MAP4K1,NPRL2,PRKACBA,GRK1A,CCL3
    protein binding TIE1,HNRNPF,EVC2,NFATC2,TBC1D7,PRDM5,MUM1,TMED2,MYH9,ATP1B1
    MAP kinase kinase kinase activity STK3,EGFR,BRAF,MAP3K1,MAP3K6,TAOK2,MAP3K14,KIAA1804,MAP3K2,MAP3K12

    Interacting Protein

    MAP3K3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K3.

    YWHAE;TRAF7;CHUK;FLNA;MAP2K5;YWHAB;YWHAE

    MAP3K3 Related Signal Pathway

    Resources

    Research Area

    Kinases and Phosphatases in Endothelial Cells
    Intracellular Kinases in the Akt Pathway
    MAP3K
    Post-translational Modification of NFkB/IkB

    References

    • Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
    • Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).

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