MAP3K13
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Official Full Name
mitogen-activated protein kinase kinase kinase 13 -
Overview
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. -
Synonyms
MAP3K13;mitogen-activated protein kinase kinase kinase 13;leucine zipper bearing kinase;LZK;MEKK13;mixed lineage kinase;leucine zipper-bearing kinase;MLK;MGC133196
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MAP3K13-3713H | Recombinant Human MAP3K13 protein, GST-tagged | E.coli | Human | GST | 706 - 839 aa | |
| MAP3K13-9509M | Recombinant Mouse MAP3K13 Protein | Mammalian Cell | Mouse | His |
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| MAP3K13-1055HCL | Recombinant Human MAP3K13 cell lysate | Human | Non |
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| MAP3K13-1940HF | Active Recombinant Full Length Human MAP3K13 Protein, GST-tagged | Insect (sf21) | Human | GST | Full L. 1-966 |
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| MAP3K13-5330M | Recombinant Mouse MAP3K13 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| MAP3K13-5330M-B | Recombinant Mouse MAP3K13 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MAP3K13 involved in several pathways and played different roles in them. We selected most pathways MAP3K13 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | FGFR4,PPP3CA,MAP3K1,ARR3A,NTF4,FGF19,PRKCG,MINK1,CDC42L,RPS6KA3B |
Protein Function
MAP3K13 has several biochemical functions, for example, ATP binding,MAP kinase kinase kinase activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K13 itself. We selected most functions MAP3K13 had, and list some proteins which have the same functions with MAP3K13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | TSSK1,STK32C,PAK6,TTBK1,EIF2AK3,CSNK2A2,MAP2K7,BMPR2A,PRKCHB,CSNK1G2B |
| metal ion binding | ZNF493,TGFBR2,PGM2L1,GALNT6,ISG20,DMRTC2,HAGH,GMEB2,TSNAX,GM5077 |
| protein binding | ZG16,CDC6,HSPB7,NPRL2,CLN6,SLC22A6,STXBP2,DRD1,KHDC3,RUVBL1 |
| protein homodimerization activity | ZFP423,VAPB,ABCG2,ABCB10,UNC13A,Trl,BMPR1A,PFKM,NUDT16,MAPK4 |
| protein kinase binding | CD226,PAX6,PTPRJ,THY1,GSK3B,TOM1L1,SMAD3,HSP90AB1,IFNAR2,GCSAM |
| MAP kinase kinase kinase activity | MAP3K14,MAP3K12,ZAK,TAOK2,TAOK3,RAF1,YSK4,MAP3K8,BRAF,STK4 |
| ATP binding | NAIP1,YME1L1,DDX41,ABCB10,SMC3,KIF5C,HIPK4,ATP2B1B,PKN3,TEC |
| identical protein binding | KIRRELA,SLC22A1,KHDC1B,UBQLN1,JMJD6,RUVBL2,PSMD4,ITGB3,HOMER1,GRIK5 |
Interacting Protein
MAP3K13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K13 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K13.
STAT3;HLA-DRB3;GLO1
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References
- Du, X; Li, YM; et al. Effect of a heat shock protein 90-specific inhibitor on the proliferation and apoptosis induced by VEGF-C in cervical cancer cells. EXPERIMENTAL AND THERAPEUTIC MEDICINE 8:1559-1564(2014).
- Mongkhon, JM; Thach, M; et al. Sorbitol-modified hyaluronic acid reduces oxidative stress, apoptosis and mediators of inflammation and catabolism in human osteoarthritic chondrocytes. INFLAMMATION RESEARCH 63:691-701(2014).
