MAP2K7
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Official Full Name
MAP2K7 mitogen-activated protein kinase kinase 7 -
Overview
The stress response of mammalian cells results in activation of kinases of the SAPK1 and SAPK2 families. The SAP kinases are specifically activated by dual phosphorylation of a conserved T-X-Y motif by MAP kinase kinases (MKK). The 3 isoforms of the SAPK1 family (SAPK1 alpha/jnk2; SAPK1 beta/jnk3; SAPK1 beta/jnk1) are synergistically activated by phosphorylation of the threonine residue by MKK7 and the tyrosine residue by MKK4. -
Synonyms
MAP2K7;mitogen-activated protein kinase kinase 7;PRKMK7;dual specificity mitogen-activated protein kinase kinase 7;Jnkk2;MKK7;MEK 7;JNKK 2;MAPKK 7;SAPK kinase 4;MAPK/ERK kinase 7;MAP kinase kinase 7;JNK-activating kinase 2;c-Jun N-terminal kinase kinase 2;stress-activated protein kinase kinase 4;MAPKK7;SAPKK4;SAPKK-4
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Insect Cells
- Sf21 Cells
- His
- T7
- Non
- GST
- Avi
- Fc
- Flag
- DDK
- Myc
Involved Pathway
MAP2K7 involved in several pathways and played different roles in them. We selected most pathways MAP2K7 participated on our site, such as MAPK signaling pathway,ErbB signaling pathway,Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | TNFSF11,NFKB2,CSF1R,TYROBP,TNFRSF11A,MAP2K1,CYLD,FOS,TYK2,IFNAR1 |
| TNF signaling pathway | MAPK13,MAPK8,LIF,Casp3,LTA,BCL3,CXCL5,FAS,IKBKG,TNFRSF1B |
| Neurotrophin signaling pathway | ARHGDIA,MAPKAPK2,CAMK2B,NGFR,MAPK13,PSEN1,NTRK2,PRKCD,MATK,RPS6KA3 |
| Toll-like receptor signaling pathway | MAPK14A,TLR1LA,TBK1,TRAF6,NFKBIAB,RAC1B,MAPK11,PIK3R5,MAPK8B,TLR4 |
| GnRH signaling pathway | CALM3A,GNAQ,MAP2K2,CALML3,CALM2B,GNRH1,CAMK2B,MAP2K2A,LHB,PRKACA |
| Fc epsilon RI signaling pathway | RAC1,PIK3CD,MAP2K1,FCER1A,BTK,PIK3R1,FCER1G,MAPK9,PLA2G4A,LAT |
| MAPK signaling pathway | TGFB3,GNA12,STK3,PLA2G4AA,PLA2G4C,TP53,HRASB,FGF10A,FGF21,FGF16 |
| ErbB signaling pathway | AREGB,CBL,NCK2,CDKN1BA,CBLB,HRAS,MAPK10,MAPK3,MAPK8,PTK2 |
| T cell receptor signaling pathway | MAPK3,CDC42,PDCD1,CD8B1,NCK1,PIK3R5,CD40LG,NFKBIE,CD3D,TNF |
Protein Function
MAP2K7 has several biochemical functions, for example, ATP binding,MAP kinase kinase activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K7 itself. We selected most functions MAP2K7 had, and list some proteins which have the same functions with MAP2K7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TPM1,GRIN2D,SHANK3,VIL1,RAB9B,NOP58,SNX33,CSNK1D,ZNF695,FAM134B |
| protein tyrosine kinase activity | CAMKK2,PTK2BB,SHC1,KDR,INSRB,FER,JAK2,MAP2K1,JAK2A,ZNF143B |
| protein serine/threonine kinase activity | CDC42BPA,GRK7A,MAP4K4,TESK2,MAPK8A,SRPK1,DAPK3,DYRK2,AKT3,SRPK2 |
| protein phosphatase binding | VCAN,FLT4,DLG4,ANAPC5,KCNN4,DRD1A,SKAP1,MVP,FGF19,PPP6R3 |
| ATP binding | RECQL,Acsm2a,RIOK3,PIP5K1B,STK31,NPR2,PEX6,MAP2K5,STK38,TRPV1 |
| MAP kinase kinase activity | MAP2K2B,MAP3K9,MAP3K14,MAPKAPK5,MAPK14,MAP2K6,LRRK2,MAPK10,MAP2K3,MAP2K2A |
| enzyme binding | MDM2,GSTM3,YWHAH,CDC20,RAD9,RPS3,PRKCH,CASC3,UBE2I,TAL1 |
| protein kinase binding | PXN,CCNL1,CDK5RAP2,CAV1,MAPKAP1,PPME1,GATA4,ERRFI1,PPP1CB,TICAM1 |
| magnesium ion binding | COMT,NT5C1BA,FARSB,IDH3A,STK11,ATP10A,ADSSL1,LATS1,PPA1B,STK4 |
Interacting Protein
MAP2K7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K7.
MAP3K7;(dtp3)-tyr,arg,phe;GADD45B;MAPK8IP1
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References
- Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).
- Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
