MAP2K4
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Official Full Name
mitogen-activated protein kinase kinase 4 -
Overview
SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines (1-3). Activation of SEK1 occurs through MEKK phosphorylation of se -
Synonyms
MAP2K4;mitogen-activated protein kinase kinase 4;SERK1;dual specificity mitogen-activated protein kinase kinase 4;JNKK1;MEK4;MKK4;PRKMK4;MEK 4;MAPKK 4;SAPK kinase 1;MAPK/ERK kinase 4;SAPK/ERK kinase 1;MAP kinase kinase 4;JNK-activated kinase
Recombinant Proteins
- Human
- Mouse
- Sf9 Cells
- Insect Cells
- E.coli
- Human
- Mammalian Cells
- HEK293
- Sf21 Cells
- Yeast
- His
- GST&His
- His&MBP
- Non
- Flag
- Avi&Fc&His
- GST
- DDK&Myc
- His&Myc
- His&SUMO
Involved Pathway
MAP2K4 involved in several pathways and played different roles in them. We selected most pathways MAP2K4 participated on our site, such as MAPK signaling pathway,ErbB signaling pathway,Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chagas disease (American trypanosomiasis) | CCL5,CASP8,IL10,IL-8,SMAD2,PLCB2,GNAI2,AKT1,PIK3R2,TGFB3 |
| Fc epsilon RI signaling pathway | SYK,MAPK8,MAPK3,MAPK1,IL3,GM-CSF,PLA2G4A,VAV3,LYN,VAV2 |
| Epithelial cell signaling in Helicobacter pylori infection | ATP6V1D,ATP6V0A1,NFKBIA,ATP6V1G2,LYN,ATP6V0D1,ATP6V1B1,ATP6V1G3,ATP6AP1,F11R |
| Influenza A | TNF,IFNA8,KPNA2,Ccl12,EIF2AK3,IL1B,MAP2K6,HLA-DRB4,EIF2AK2,HSPA1L |
| Hepatitis B | TICAM2,PIK3CD,CREB3L3,IFNB1,TBK1,PTK2B,PCNA,IFNA7,STAT2,FASLG |
| Epstein-Barr virus infection | POLR3B,POLR2F,NFKBIE,PIK3CG,BCL2,PSMC4,PSMC3,SPI1,RB1,ITGAL |
| Toll-like receptor signaling pathway | PIK3R5,RIPK1L,MAPK8,TLR1LB,IL8L2,TLR4BB,MAPK3,MAPK12B,MAPK10,IFNA21 |
| TNF signaling pathway | TRAF5,FADD,MAP2K3,PIK3R2,IL6,PIK3R3,VEGFC,LIF,MAP2K1,MAGI2 |
| MAPK signaling pathway | PRKACG,MAP2K4B,MOS,CACNB1,MEF2C,HSPA8,FGF4,STMN1,CACNG8,HSC70 |
Protein Function
MAP2K4 has several biochemical functions, for example, ATP binding,protein binding,protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K4 itself. We selected most functions MAP2K4 had, and list some proteins which have the same functions with MAP2K4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase activity | EIF2AK3,EPHA4,PRPF4B,ACVR1L,MAP2K1,MAP2K5,ULK1A,FASTKD1,MAP3K2,TEK |
| protein binding | DMAP1,VEGFA,KIF20A,TRIM26,NKX2-1,TXLNG,GEMIN6,TRIM40,DCBLD2,AKAP12 |
| protein tyrosine kinase activity | MAP2K1,TTK,KITB,HCK,FGFR1A,NEK1,MATK,PTK2BB,FYNB,ROS1 |
| ATP binding | SPS2,PASK,KHK,CSNK2A1,NEK4,YES1,DCLK3,MLH1,MAT2AA,DDX21 |
| protein serine/threonine kinase activity | TRIO,MASTL,PLK1,SGK2B,MAPK6,VRK2,DMPK,DAPK2,CAMK2A,TAF1L |
Interacting Protein
MAP2K4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K4.
MAP3K1;ARRB2;MAPK8;ARRB1;CFLAR;yopP;Arrb2;TRIB1;FBP2;ALDOB;MAPK9;STX17;CYLC2;RBBP8;pi3p;npm_alk
MAP2K4 Related Signal Pathway
Resources
Research Area
Tumor SuppressorsApoptosis Intracellular Kinases
Intracellular Kinases in the Akt Pathway
Mitogen-Activated Protein Kinase Kinases (MEKs/MKKs)
NOD-like Receptors and the Inflammasome
IL-1 Family Signaling Molecules
Osteosarcoma Biomarkers
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References
