MADD
-
Official Full Name
MAP-kinase activating death domain -
Overview
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. -
Synonyms
MADD;MAP-kinase activating death domain;MAP kinase-activating death domain protein;DENN;KIAA0358;RAB3GEP;Rab3 GDP/GTP exchange factor;insulinoma glucagonoma clone 20;differentially expressed in normal and neoplastic cells;IG20;FLJ35600;FLJ36300
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MADD-3530R | Recombinant Rat MADD Protein | Mammalian Cells | Rat | His |
|
|
| MADD-4566HCL | Recombinant Human MADD 293 Cell Lysate | HEK293 | Human | Non |
|
|
| Madd-1755R | Recombinant Rat Madd Protein, His-tagged | E.coli | Rat | His | Arg1291-Ser1602 |
|
| MADD-2409H | Recombinant Human MADD Protein, His-tagged | E.coli | Human | His | Asn1388-Ser1647 |
|
| MADD-3186R | Recombinant Rat MADD Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| MADD-3186R-B | Recombinant Rat MADD Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
Involved Pathway
MADD involved in several pathways and played different roles in them. We selected most pathways MADD participated on our site, such as Aminoacyl-tRNA biosynthesis,Cytosolic tRNA aminoacylation,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MADD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aminoacyl-tRNA biosynthesis | SARS2,NARS,PET112L,TARS2,YARS,FARSB,EPRS,MARS2,RARS2,CARS |
| Gene Expression | ZNF777,ZNF264,EIF2S3,SAP30,ZNF224,HUG,ZNF740,SNAPC1,TET1,ZNF436 |
| tRNA Aminoacylation | EARS2,AIMP1,DARS,WARS2,AARS,AIMP2,FARS2,EEF1E1,KARS,FARSB |
| Cytosolic tRNA aminoacylation | AARS,AIMP2,KARS,EEF1E1,FARSB,AIMP1,DARS |
Protein Function
MADD has several biochemical functions, for example, ATP binding,interleukin-8 receptor binding,NOT isoleucine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MADD itself. We selected most functions MADD had, and list some proteins which have the same functions with MADD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-8 receptor binding | YARS,IL-8 |
| poly(A) RNA binding | SLC25A11,CHCHD1,NOP56,HSD17B10,HDAC2,TSNAX,BCCIP,GNL3,ZRANB2,DHX34 |
| tyrosine-tRNA ligase activity | YARS,YARS2 |
| NOT isoleucine-tRNA ligase activity | YARS |
| tRNA binding | PSTK,AARS2,RARS,AIMP1,METTL1,THG1L,SSB,DARS2,ALKBH8,MARS |
| ATP binding | MCM5,CHEK2,TAE1,PANK4,PRKCDA,ABCA5,ITK,HSP90AA1,SNRNP200,UBE2N |
| signal transducer activity | CHRM5A,TAAR13C,TAS2R106,CALCRLA,VMN1R40,TAAR7B,EXORH,V2RX1,FPR-RS6,ATP2C1 |
Interacting Protein
MADD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MADD here. Most of them are supplied by our site. Hope this information will be useful for your research of MADD.
PTPRN;POT1;YWHAZ;acnA;VPS13D;RB1CC1;WNK1
Resources
Related Services
Related Products
References
