MACC1
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Official Full Name
metastasis associated in colon cancer 1 -
Overview
MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860);pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility,;invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic;indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 (PubMed 19098908)). -
Synonyms
MACC1;metastasis associated in colon cancer 1;metastasis-associated in colon cancer protein 1;7A5;SH3BP4L;putative binding protein 7a5;SH3 domain-containing protein 7a5
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- His&Fc&Avi
- His&GST
- Myc&DDK
- GST
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MACC1-680H | Recombinant Human MACC1, His-tagged | E.coli | Human | His | C-351aa | |
| MACC1-7879Z | Recombinant Zebrafish MACC1 | Mammalian Cells | Zebrafish | His |
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| MACC1-1336H | Recombinant Human MACC1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| MACC1-1336H-B | Recombinant Human MACC1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| MACC1-1427H | Recombinant Human MACC1 protein, His & GST-tagged | E.coli | Human | His&GST | Gln522-Met784 |
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| MACC1-177H | Recombinant Human MACC1 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| Macc1-3891M | Recombinant Mouse Macc1 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| MACC1-4255H | Recombinant Human MACC1 Protein (Gln522-Met784), N-GST tagged | E.coli | Human | GST | Gln522-Met784 |
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| MACC1-5272H | Recombinant Human MACC1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| MACC1-823HFL | Recombinant Full Length Human MACC1 Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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Involved Pathway
MACC1 involved in several pathways and played different roles in them. We selected most pathways MACC1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MACC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MACC1 has several biochemical functions, for example, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MACC1 itself. We selected most functions MACC1 had, and list some proteins which have the same functions with MACC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | IL10,BDNF,BTC,NUDT6,CECR1,MIA,HDGFRP3,NRG3,GDF3,MDKA |
Interacting Protein
MACC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MACC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MACC1.
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References
- Satelli, A; Mitra, A; et al. Epithelial-Mesenchymal Transitioned Tumor Cells Capture for Detecting Tumor Progression. CLINICAL CANCER RESEARCH 21:899-906(2015).
- Ahn, SB; Chan, C; et al. Epithelial and Stromal Cell Urokinase Plasminogen Activator Receptor Expression Differentially Correlates with Survival in Rectal Cancer Stages B and C Patients. PLOS ONE 10:-(2015).
