LTC4S
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Official Full Name
leukotriene C4 synthase -
Overview
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. -
Synonyms
LTC4S;leukotriene C4 synthase;MGC33147;Leukotriene C(4) synthase;LTC4 synthase;OTTHUMP00000197039
Recombinant Proteins
- Human
- Rat
- Mouse
- Mus musculus
- Guinea pig
- Bovine
- Insect Cells
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
- Flag
Involved Pathway
LTC4S involved in several pathways and played different roles in them. We selected most pathways LTC4S participated on our site, such as Arachidonic acid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with LTC4S were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | CYP2Y3,DPEP2,GPX1A,GGT5,FAAH2,CYP2B19,MAPKAPK2B,PTGS1,CYP4F2,CYP2J5 |
| Metabolic pathways | ENOPH1,ODC1,FH,MTMR14,PGAM1B,GPI1,SAT1A.1,PGLS,POLR2J3,GBGT1L4 |
Protein Function
LTC4S has several biochemical functions, for example, enzyme activator activity,glutathione binding,glutathione peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LTC4S itself. We selected most functions LTC4S had, and list some proteins which have the same functions with LTC4S. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione transferase activity | GSTT2,MGST2,GSTA4,GSTK1,GSTA5,HPGDS,GSTA1,GSTT1,GSTM5,GSTZ1 |
| lipid binding | APOL6,PITPNC1,SH3GL2,EPN2,RASGRP1,ACBD5,BAIAP2L2B,FABP9,DBIL5,APODB |
| protein binding | GLS,IL6ST,C11orf57,RUSC1,POLI,RASD1,TMEM242,ROCK1,WARS,ATF6 |
| leukotriene-C4 synthase activity | MGST2 |
| glutathione peroxidase activity | GPX4B,GPX3,MGST1,MGST2,GPX1,CLIC2,GPX1B,GPX4,PRDX6,GPX5 |
| glutathione binding | PTGES2,GSTM4,GSTM2,MGST1,GSTM1,LANCL1,GSTM3,GSS,PTGESL,GPX1 |
| protein heterodimerization activity | H3F3A,PVALB,MAFG,BTBD11,HIST1H2AL,BAXB,HGF,NFKB1,TLR6,UGT1A4 |
| enzyme activator activity | ARL1,PITRM1,GTF3C4,MGST2,GM1679,PPP1R12B,CLPSL1,PSAP,CLPS,SFTPBB |
Interacting Protein
LTC4S has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LTC4S here. Most of them are supplied by our site. Hope this information will be useful for your research of LTC4S.
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References
- Boger, PC; Shutt, JD; et al. Increased expression of the 5-lipoxygenase pathway and its cellular localization in Barrett's adenocarcinoma. HISTOPATHOLOGY 61:509-517(2012).
- Queto, T; Gaspar-Elsas, MI; et al. Cysteinyl-leukotriene type 1 receptors transduce a critical signal for the up-regulation of eosinophilopoiesis by interleukin-13 and eotaxin in murine bone marrow. JOURNAL OF LEUKOCYTE BIOLOGY 87:885-893(2010).
