LSM4
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Official Full Name
LSM4 homolog, U6 small nuclear RNA associated -
Overview
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind;specifically to the 3-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6;snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this;gene. -
Synonyms
LSM4;LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae);U6 snRNA-associated Sm-like protein LSm4;YER112W;glycine-rich protein;GRP
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- T7
- Non
- His&Fc&Avi
- His&SUMO
Involved Pathway
LSM4 involved in several pathways and played different roles in them. We selected most pathways LSM4 participated on our site, such as RNA degradation,Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with LSM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | PRPF3,SF3B6,DDX5,USP39,U2AF1,EIF4A3,SRSF10,RBM25,RBM8A,PPIH |
| RNA degradation | DIS3L,BTG2,ENO1A,HSPD1,DHX36,DCP1A,LSM7,BTG3,XRN1,PABPC5 |
Protein Function
LSM4 has several biochemical functions, for example, U6 snRNA binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LSM4 itself. We selected most functions LSM4 had, and list some proteins which have the same functions with LSM4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | SNRPA,MRPS28,DDX39A,SUB1,RPUSD4,TFAM,DNM1,RBM4,HEATR6,PRPF3 |
| U6 snRNA binding | LSM7,LSM2,RBM22,PRPF8,EIF5A,DDX39B,PRPF4,LSM8,SART3 |
| protein binding | TSN,ABCG8,DYNC1LI1,EN1,NGLY1,BUD31,KIF23,KIAA0101,ARMC8,CARD11 |
Interacting Protein
LSM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LSM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of LSM4.
CALCOCO2;LSM7;PSTPIP1;IKZF1;ZBTB10;L3MBTL3
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References
- Eystathioy, T; Peebles, CL; et al. Human anti-Sm antibodies recognize LSm4 and LSm heptameric complex.. ARTHRITIS AND RHEUMATISM 43:S327-S327(2000).
- Schneider, MD; Najand, N; et al. Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development. JOURNAL OF CELL BIOLOGY 174:349-358(2006).
- Eystathioy, T; Peebles, CL; et al. Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera. ARTHRITIS AND RHEUMATISM 46:726-734(2002).
