LRRN2
-
Official Full Name
leucine rich repeat neuronal 2 -
Overview
The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. -
Synonyms
LRRN2;leucine rich repeat neuronal 2;leucine rich repeat neuronal 5 , LRRN5;leucine-rich repeat neuronal protein 2;fibronectin type III;immunoglobulin and leucine rich repeat domain 7;FIGLER7;GAC1;leucine rich and ankyrin repeats 1;LRANK1;Fibronectin type III immunoglobulin and leucine rich repeat domain 7;GAC 1;Glioma amplified on chromosome 1;Glioma amplified on chromosome 1 protein;Leucine rich repeat neuronal 5;Leucine rich repeat neuronal protein 2;Leucine rich repeat neuronal protein 5;LRANK 1;LRRN 2;LRRN 5;OTTHUMP00000034222;OTTHUMP00000035083;leucine-rich repeat neuronal protein 5;fibronectin type III, immunoglob;LRRN5
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LRRN2-29432TH | Recombinant Human LRRN2, His-tagged | E.coli | Human | His | 333-549 a.a. |
|
| LRRN2-4618HCL | Recombinant Human LRRN2 293 Cell Lysate | HEK293 | Human | Non |
|
|
| LRRN2-4631H | Recombinant Human LRRN2 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| LRRN2-6081HF | Recombinant Full Length Human LRRN2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 713 amino acids |
|
| RFL5342HF | Recombinant Full Length Human Leucine-Rich Repeat Neuronal Protein 2(Lrrn2) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length of Mature Protein (19-713) |
|
Involved Pathway
LRRN2 involved in several pathways and played different roles in them. We selected most pathways LRRN2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LRRN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
LRRN2 has several biochemical functions, for example, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LRRN2 itself. We selected most functions LRRN2 had, and list some proteins which have the same functions with LRRN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | TLR1,IL18R1,CD33,CMKLR1,NLGN3,LILRB2,TNFRSF6B,SLC20A2,SIGLEC7,ANTXR2B |
Interacting Protein
LRRN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRRN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRRN2.
NEUROD4
Resources
Related Services
Related Products
References
- West, AB; Cowell, RM; et al. Differential LRRK2 Expression in the Cortex, Striatum, and Substantia Nigra in Transgenic and Nontransgenic Rodents. JOURNAL OF COMPARATIVE NEUROLOGY 522:2465-2480(2014).
- Daher, JPL; Volpicelli-Daley, LA; et al. Abrogation of alpha-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:9289-9294(2014).
