LPAR3
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Official Full Name
lysophosphatidic acid receptor 3 -
Overview
This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. -
Synonyms
LPAR3;lysophosphatidic acid receptor 3;EDG7, endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 7;Edg 7;HOFNH30;LP A3;LPA3;RP4 678I3;LPA-3;LPA receptor 3;LPA receptor EDG7;lysophosphatidic acid receptor Edg-7;endot
Recombinant Proteins
- Human
- Rat
- Chicken
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Myc
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LPAR3-618H | Recombinant Human LPAR3, GST-tagged | E.coli | Human | GST | C-60aa | |
| LPAR3-3435R | Recombinant Rat LPAR3 Protein | Mammalian Cells | Rat | His |
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| LPAR3-3809C | Recombinant Chicken LPAR3 | Mammalian Cells | Chicken | His |
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| LPAR3-4023H | Recombinant Human LPAR3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| LPAR3-8383Z | Recombinant Zebrafish LPAR3 | Mammalian Cells | Zebrafish | His |
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| LPAR3-4673HCL | Recombinant Human LPAR3 293 Cell Lysate | HEK293 | Human | Non |
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| LPAR3-1187H | Recombinant Human LPAR3 protein, His&Myc-tagged | E.coli | Human | His&Myc | 298-353aa |
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| LPAR3-3091R | Recombinant Rat LPAR3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| LPAR3-3091R-B | Recombinant Rat LPAR3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| LPAR3-4693HF | Recombinant Full Length Human LPAR3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 353 amino acids |
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| LPAR3-4725H | Recombinant Human LPAR3 Protein | Wheat Germ | Human | Non |
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| LPAR3-5970HF | Recombinant Full Length Human LPAR3 Protein | In Vitro Cell Free System | Human | Full L. 600 amino acids |
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Involved Pathway
LPAR3 involved in several pathways and played different roles in them. We selected most pathways LPAR3 participated on our site, such as Rap signaling pathway,Phospholipase D signaling pathway,Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPAR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | COL27A1,FLT4,ATF4,COL6A5,IFNA10,CREB3L3,GYS2,RELA,KITLG,LPAR2 |
| Rap signaling pathway | TEK,CALM2,F2R,FYB,SKAP1,PLCB2,IGF1R,PIK3R1,FGF1,CALM3 |
| Phospholipase D signaling pathway | PLA2G4C,SHC3,LPAR5,NRAS,PLCB4,PLD2,INS1,MAPK3,PPAP2A,LPAR2 |
| Neuroactive ligand-receptor interaction | TAAR10A,HTR6,GABRB2,TAAR12A,CHRNA3,LTB4R2,BDKRB2,GRIK1,VIPR1,PTH1RB |
| Pathways in cancer | LAMA2,CBLB,FGF20,RXRG,CXCL12,ROCK2,RASGRP3,FZD9,SMAD3,ARNT |
Protein Function
LPAR3 has several biochemical functions, for example, G-protein alpha-subunit binding,G-protein coupled receptor activity,lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LPAR3 itself. We selected most functions LPAR3 had, and list some proteins which have the same functions with LPAR3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | GPR146,ADRB2A,NPFFR2,GPR6,OPN1MW1,RPA1,GPR12,RXFP1,TAAR14J,TAAR1 |
| lysophosphatidic acid receptor activity | LPAR6A,LPAR2B,LPAR2A,LPAR2,LPAR1 |
| phospholipid binding | BIN2,VAMP2,ABCA1,PSD4,PLEKHA3,APOM,SNCA,WDFY4,ANXA1,APOEA |
| lipid binding | FABP5,RASGRP1,BPIFB2,AP2M1A,HDLBP,ACBD6,BPIFB3,OSBPL11,PLUNC,FABP7A |
| G-protein alpha-subunit binding | RGS19,F2R,DRD1,ADRB2,DRD1A,NUCB1,RIC8A,OPRM1,HTR2A,RIC8 |
Interacting Protein
LPAR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPAR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of LPAR3.
Resources
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References
- Shen, JY; Zhou, CL; et al. Comparative Transcriptome Analysis Reveals Early Pregnancy-Specific Genes Expressed in Peripheral Blood of Pregnant Sows. PLOS ONE 9:-(2014).
- Uchida, H; Nagai, J; et al. Lysophosphatidic acid and its receptors LPA(1) and LPA(3) mediate paclitaxel-induced neuropathic pain in mice. MOLECULAR PAIN 10:-(2014).
