LPA
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Official Full Name
lipoprotein, Lp(a) -
Overview
Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is a condition in which an artery wall thickens as a result of the accumulation of fatty materials such as cholesterol. It is a syndrome affecting arterial blood vessels, a chronic inflammatory response in the walls of arteries, caused largely by the accumulation of macrophage white blood cells and promoted by low-density lipoproteins (plasma proteins that carry cholesterol and triglycerides) without adequate removal of fats and cholesterol from the macrophages by functional high density lipoproteins (HDL), (see apoA-1 Milano). It is commonly referred to as a hardening or furring of the arteries. It is caused by the formation of multiple plaques within the arteries. -
Synonyms
Oxidized Lipoprotein (a);Oxidized Lp (a);Lipoprotein(a) Oxidized-Lp(a);Oxidized Lipoprotein;LPA
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LPA-7813H | Recombinant Human LPA protein, His-tagged | E.coli | Human | His | Asp1719~Arg2038 |
|
| LPA-352L | Native Legionella Pneumophila Antigen Protein | LP | LP | Non |
|
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| LPA-8453H | Native Human LPA | Human Plasma | Human | Non |
|
Involved Pathway
LPA involved in several pathways and played different roles in them. We selected most pathways LPA participated on our site, such as LDL-mediated lipid transport,Lipid digestion, mobilization, and transport,Lipoprotein metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| amb2 Integrin signaling | ELANE,MST1R,NIPAL1,MST1,CYR61,HP |
| Lipid digestion, mobilization, and transport | CLPS,FABP9,APOA1B,MTP,APOA4A,FABP11A,APOA5,APOBB.1,APOA4B.1,ABCA1 |
| LDL-mediated lipid transport | APOBB.1,CETP,APOF |
| Metabolism | ITPKA,AQP1A.1,NUDT3B,ACOT7,ARV1,SULT1C4,CERS4A,CYP27A1,LBR,DAO |
| Lipoprotein metabolism | APOEB,MTP,APOA4B.1,APOA4A,APOA5,APOC2,APOF,APOA1B,Alb,ABCA1 |
| Metabolism of lipids and lipoproteins | APOC2,SGMS2,GLTPA,CERS5,SLC27A2A,ACOT11,CPT2,DHCR24,CPNE1,DHCR7 |
Protein Function
LPA has several biochemical functions, for example, apolipoprotein binding,endopeptidase inhibitor activity,fibronectin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LPA itself. We selected most functions LPA had, and list some proteins which have the same functions with LPA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| apolipoprotein binding | LPL,LRP1,LRP4,VLDLR,PCSK9,PLG,LIPC,MAPT,SCARB1,LRP6 |
| serine-type endopeptidase activity | LOC780933,PCSK5B,HPN,ST14B,ST14,AZU1,TRY,PRTN3,TMPRSS13A,KLK1B16 |
| heparin binding | CCL7,SOST,SERPINA5,COL25A1,CTGF,BMP7,ADAMTS3,APPA,CYR61L1,THBS1 |
| protein binding | ACBD3,TOX4,FAM83A,ZNF433,TK1,NIPSNAP1,BMP7,HGD,BLOC1S4,USP49 |
| endopeptidase inhibitor activity | Serpina1b,RENBP,ITIH2,STFA1,STFA2,SPINK1,PROS1,SERPINF2,PZP,A2ML |
| fibronectin binding | LRRC15,IGFBP5,ITGB1,ITGB3,IGFBP5A,VEGFA,CTSK,CTSL1,IGFBP5B,CTSS |
Interacting Protein
LPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPA here. Most of them are supplied by our site. Hope this information will be useful for your research of LPA.
APOH;FN1
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References
- Leblanc, R; Lee, SC; et al. Interaction of platelet-derived autotaxin with tumor integrin alpha(V)beta(3) controls metastasis of breast cancer cells to bone. BLOOD 124:3141-3150(2014).
- Li, J; Wang, G; et al. Transforming growth factor beta regulates beta-catenin expression in lung fibroblast through NF-kappa B dependent pathway. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34:1219-1224(2014).
