LOXL3
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Official Full Name
lysyl oxidase-like 3 -
Overview
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the;biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first;step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus;end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function.;The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor;suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript;variants of this gene have been reported but their full-length nature has not been determined. -
Synonyms
LOXL3;lysyl oxidase-like 3;LOXL;lysyl oxidase homolog 3;lysyl oxidase-like protein 3;EC 1.4.3.13
Recombinant Proteins
- Human
- Mouse
- CHO
- Sf9 Insect Cell
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- His
- GST
- His&GST
- His&Myc
- His&Fc&Avi
Involved Pathway
LOXL3 involved in several pathways and played different roles in them. We selected most pathways LOXL3 participated on our site, such as Assembly of collagen fibrils and other multimeric structures,Collagen formation,Crosslinking of collagen fibrils, which may be useful for your reference. Also, other proteins which involved in the same pathway with LOXL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Collagen formation | PCOLCEA,COL5A1,CTSB,COL5A2,COL11A1B,COL5A3A,TLL2,COL9A1,ABHD1,COL5A3B |
| Extracellular matrix organization | MUSK,ITGB3A,MFAP2,COL8A1A,COL15A1B,COL4A6,ADAMTS8,COL28A1D,LOC100514666,MMP20 |
| Elastic fibre formation | MFAP5,EFEMP2,BMP10,FURINA,LOXL2,MFAP4,EFEMP1,MFAP1B,FBLN2,FBN1 |
| Crosslinking of collagen fibrils | BMP1A,LOXL1,PCOLCE,LOX,ABHD1,TLL1,BMP1B,LOXL4,TLL2,LOXL2 |
| Assembly of collagen fibrils and other multimeric structures | COL5A1,COL1A2,CD151,COL4A4,LOXL4,MMP20,COL11A1B,LOXL1,COL3A1,COL5A3B |
Protein Function
LOXL3 has several biochemical functions, for example, copper ion binding,protein binding,protein-lysine 6-oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LOXL3 itself. We selected most functions LOXL3 had, and list some proteins which have the same functions with LOXL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein-lysine 6-oxidase activity | LOXL2,LOXL2B,LOX,LOXL2A,POLR1B,ABHD1,LOXL4 |
| protein binding | NUP153,TNFAIP8L1,WHSC1L1,RNF19B,SMARCA4,UBR1,KLHL41,RAB27A,SKI,SELPLG |
| copper ion binding | LOXL3B,P2RX4,CP,PRNPA,IL1A,AOC2,LOX,LOXL2B,PRND,SNAI3 |
| scavenger receptor activity | TMPRSS2,LOXL4,TMPRSS15,POLR1B,C8orf84,LOXL3A,CD163,PRSS12,TMPRSS4,CD163L1 |
Interacting Protein
LOXL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LOXL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of LOXL3.
GATAD2B;APMAP
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