LMAN2
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Official Full Name
lectin, mannose-binding 2 -
Overview
This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. -
Synonyms
LMAN2;lectin, mannose-binding 2;C5orf8, chromosome 5 open reading frame 8;vesicular integral-membrane protein VIP36;GP36B;VIP36;glycoprotein GP36b;vesicular integral protein of 36 kDa;vesicular integral-membrane protein 36;C5orf8
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Dog
- HEK293
- Mammalian Cells
- E.coli
- HIS
- His
- Non
- Myc&DDK
- His&Fc&Avi
- N-His-HA
Involved Pathway
LMAN2 involved in several pathways and played different roles in them. We selected most pathways LMAN2 participated on our site, such as Asparagine N-linked glycosylation,COPII (Coat Protein 2) Mediated Vesicle Transport,Cargo concentration in the ER, which may be useful for your reference. Also, other proteins which involved in the same pathway with LMAN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Asparagine N-linked glycosylation | TMED2,GORASP1,MAN1B1,NAPAA,MAN1A2,GOLGA2,ST6GAL2B,ALG14,PREB,GNE |
| Post-translational protein modification | UBA2,NANP,ADAMTS18,ADAMTS3,SEC22C,MPDU1A,ARSD,ALG10B,DPH3,STT3A |
| Protein processing in endoplasmic reticulum | BCL2,SEC23B,TRAF2,EIF2AK1,CAPN1A,HYOU1,SVIP,CKAP4,HSP70L,SELS |
| Metabolism of proteins | ADAMTSL5,SLC34A2A,ATP6AP2,TIMM17B,GNE,ADAMTSL4,SCFD1,MPDU1,TIMM13,IGF2B |
| Membrane Trafficking | TPD52L1,NSFB,AP3S1,TRAPPC5,PICALM,TRAPPC10,GJB5,NECAP1,BLOC1S4,GJA8 |
| Cargo concentration in the ER | AREG,CNIH3,TMED10,CNIH2,SEC23A,LMAN2L,CTSC,MIA3,TMED2,SEC24A |
| COPII (Coat Protein 2) Mediated Vesicle Transport | TRAPPC6BL,CTSC,TRAPPC9,SCFD1,YKT6,ANKRD28,SEC24A,SEC23A,NAPG,AREG |
| ER to Golgi Anterograde Transport | TMED10,CTSC,NAPAB,SEC24A,CTAGE5,SEC16B,PPP6R1,CTSZ,TRAPPC5,TRAPPC2L |
Protein Function
LMAN2 has several biochemical functions, for example, carbohydrate binding,glycoprotein binding,heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LMAN2 itself. We selected most functions LMAN2 had, and list some proteins which have the same functions with LMAN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heat shock protein binding | TFAM,CDC37,HSPA1A,PPP5C,NFKBIA,APAF1,DNAJA4,FKBP4,PACRG,HSPA1B |
| glycoprotein binding | SELP,CANX,CNTN1,FGFR1,LCK,RASA1,VIM,FBXO27,RGMA,STX1A |
| metal ion binding | Adcy4,PPM1F,AGFG1B,RORAA,DDAH1,ZDHHC23B,Itga10&Itgb1,NDUFV2,SUMF1,TRIM30A |
| mannose binding | CD209,MBL1,CLN5,COLEC10,CD209B,Acr,MAN2B1,LMAN2L,IGF2R,BSG |
| carbohydrate binding | BCAN,KLRF1,SBP,HBL3,LGALS14,REG3B,LGALS2,ZP3,MLEC,CD209 |
Interacting Protein
LMAN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LMAN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LMAN2.
env;SUPT5H;MAPK9;FRAT1;ATP13A2;15-deoxy-delta(12,14;1C;env;P
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References
- Mendling, W; et al. Guideline: Vulvovaginal Candidosis (AWMF 015/072), S2k (excluding chronic mucocutaneous candidosis). MYCOSES 58:1-15(2015).
- Ribeiro, CH; Lynch, NJ; et al. Deficiency in Mannose-Binding Lectin-Associated Serine Protease-2 Does Not Increase Susceptibility to Trypanosoma cruzi Infection. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 92:320-324(2015).
