LINGO1
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Official Full Name
leucine rich repeat and Ig domain containing 1 -
Overview
Leucine rich repeat and Ig domain containing 1 also known as LINGO-1 is a protein which in humans is encoded by the LINGO1 gene. -
Synonyms
LINGO1;leucine rich repeat and Ig domain containing 1;leucine rich repeat neuronal 6A , LRRN6A;leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1;FLJ14594;LERN1;leucine rich repeat neuronal 6A;leucine-rich repeat neuronal protein 1;leucine-rich repeat neuronal protein 6A;leucine-rich repeat and immunoglobilin domain-containing protein 1;LRRN6A;UNQ201;MGC17422
Recombinant Proteins
- Chicken
- Mouse
- Human
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Mammalian Cell
- HEK293
- E.coli
- HEK293T
- Yeast
- Mammalian cells
- E.coli expression system
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
- Fc
Involved Pathway
LINGO1 involved in several pathways and played different roles in them. We selected most pathways LINGO1 participated on our site, such as Axonal growth inhibition (RHOA activation),BDNF signaling pathway,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LINGO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | EMR4,MKS1,SOX9A,PPY,EMR1,ANXA1B,AKAP13,RHOT2,DHRS4,RTN4 |
| BDNF signaling pathway | CNR1,CSNK2A1,FRS2,SIRPA,GNB2L1,YBX1,KCNN2,DOK5,EEF2,EGR1 |
| p75NTR regulates axonogenesis | RTN4A,RTN4,ARHGEF1B,LINGO1B,OMG |
| p75 NTR receptor-mediated signalling | AATF,OMG,PRDM4,RTN4A,ARHGEF1B,LINGO1B,RTN4 |
| Axonal growth inhibition (RHOA activation) | OMG,RTN4,LINGO1B,ARHGEF1B,RTN4A |
| Signalling by NGF | RTN4,DNAL4A,ARHGEF1B,RIT1,OMG,LINGO1B,AATF,RIT2,DNAL4,KIDINS220B |
Protein Function
LINGO1 has several biochemical functions, for example, epidermal growth factor receptor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LINGO1 itself. We selected most functions LINGO1 had, and list some proteins which have the same functions with LINGO1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PCMT1,DICER1,TUBA1B,EPC1,MAPRE2,MICU1,PAN2,L3MBTL4,PTH2R,ZBTB33 |
| epidermal growth factor receptor binding | ERBB4,SOCS5,ARF4,EREG,TNK2,ATXN2,HBEGF,SHC1,CBLC,HBEGFB |
Interacting Protein
LINGO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LINGO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LINGO1.
TRIM27;GOLGA2;SPAG5;EFEMP2;FBXW7;KRTAP4-12
Resources
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References
- Dubessy, AL; Zujovic, V; et al. Biotherapies in multiple sclerosis: A step toward remyelination and neuroprotection?. REVUE NEUROLOGIQUE 170:770-778(2014).
- Knier, B; Hemmer, B; et al. Novel monoclonal antibodies for therapy of multiple sclerosis. EXPERT OPINION ON BIOLOGICAL THERAPY 14:503-513(2014).
