LILRA2
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Official Full Name
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 -
Overview
This gene encodes a member of the leukocyte Ig-like receptor (LIR) family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The LIR family comprises of activating (subfamily A) and inhibitory (subfamily B) cell-surface receptors. The LIR encoded by this gene was shown to be an activating receptor for eosinophils that elicited the release of cytotoxic granule proteins, de novo lipid mediator generation, and cytokine release through vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
LILRA2;leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2;leukocyte immunoglobulin-like receptor subfamily A member 2;CD85h;ILT1;LIR 7;LIR7;CD85 antigen-like family member H;ILT-1;Immunoglobulin like transcript 1;Immunoglobulin-like transcript 1;Leukocyte immunoglobulin like receptor 7;Leukocyte immunoglobulin like receptor subfamily A member 2;Leukocyte immunoglobulin-like receptor 7;LIR-7;LIRA2_HUMAN;OTTHUMP00000068394;OTTHUMP00000068395;OTTHUMP00000068396;OTTHUMP00000068397;leuko
Recombinant Proteins
- Human
- Rhesus macaque
- HEK293
- Mammalian Cells
- E.coli
- Avi
- His
- T7
- Non
- Fc
Involved Pathway
LILRA2 involved in several pathways and played different roles in them. We selected most pathways LILRA2 participated on our site, such as Adaptive Immune System,Immune System,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with LILRA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | TNFRSF11B,IFNGR1,FCGR2B,PIK3CB,PPP3R2,PIK3R1,TRAF6,MAPK12,NFKB1,TNF |
| Immune System | ATG7,IFIT3,ARIH2,TAX1BP1,CR1,CD300A,CFHL4,KIF18A,TPP2,ATP6V1G3 |
| Adaptive Immune System | FRS2B,ASB3,KIF3C,CLEC2B,MGC174155,CYBA,PIK3AP1,Mill2,CD200R3,DZIP3 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | TREML2,LILRB1,SIGLEC8,Siglece,HCST,NCR3LG1,CD300A,SLAMF6,CLEC2H,CD300LG |
Protein Function
LILRA2 has several biochemical functions, for example, antigen binding,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LILRA2 itself. We selected most functions LILRA2 had, and list some proteins which have the same functions with LILRA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| antigen binding | KIR2DL3,FCN3,Ighg2b,MHC1UKA,Ighg,LILRB4,Ighg2a,LAG3,LILRA1,IL7R |
| receptor activity | PVRL4,CD7,CD5,RRBP1B,GRIA4A,EIF2D,NR2C1,DARC,CD200R3,TNFRSF25 |
Interacting Protein
LILRA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LILRA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LILRA2.
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