LGI1
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Official Full Name
leucine-rich, glioma inactivated 1 -
Overview
This gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. [provided by RefSeq, Jul 2008] -
Synonyms
LGI1;leucine-rich, glioma inactivated 1;EPT;ETL1;ADLTE;ADPAEF;ADPEAF;IB1099;EPITEMPIN;leucine-rich glioma-inactivated protein 1;epitempin-1
Recombinant Proteins
- Rhesus macaque
- Rat
- Chicken
- Mouse
- Human
- Mammalian Cells
- HEK293
- Wheat germ cell free in vitro
- E.coli
- Yeast
- Insect cells
- His
- Non
- GST
- Avi
- Fc
- Myc
- PDI
Involved Pathway
LGI1 involved in several pathways and played different roles in them. We selected most pathways LGI1 participated on our site, such as Developmental Biology,LGI-ADAM interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with LGI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| LGI-ADAM interactions | LGI3,LGI2B,LGI1A,LGI2A,CACNG8A,LGI4,STX1B,ADAM23,ADAM22,LGI1B |
| Developmental Biology | MYL9,FRS3,SHB,DNM2,CSNK2A2,MYL12A,NR2F2,CEBPA,FRS2A,EFNA3 |
Protein Function
LGI1 has several biochemical functions, for example, protein binding,receptor binding,NOT receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LGI1 itself. We selected most functions LGI1 had, and list some proteins which have the same functions with LGI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | HSD17B4,FGF11,LPL,TNFSF18,NPY,IAPP,FGF20B,NUDT7,EPHX2,STRAP |
| NOT receptor binding | BMX,STYK1,BTK,ITK,TXK,TEC |
| protein binding | C12orf5,RANBP6,GBP1,CCNT1,GRAMD3,SGIP1,C21orf119,PPAP2B,CD74,CCNL2 |
Interacting Protein
LGI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LGI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LGI1.
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References
- Huda, S; Wong, SH; et al. An 11-year retrospective experience of antibodies against the voltage-gated potassium channel (VGKC) complex from a tertiary neurological centre. JOURNAL OF NEUROLOGY 262:418-424(2015).
- Agazzi, P; Bien, CG; et al. Over 10-year follow-up of limbic encephalitis associated with anti-LGI1 antibodies. JOURNAL OF NEUROLOGY 262:469-470(2015).
