LEFTY2
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Official Full Name
left-right determination factor 2 -
Overview
This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants. -
Synonyms
LEFTY2;left-right determination factor 2;EBAF, endometrial bleeding associated factor (left right determination, factor A;transforming growth factor beta superfamily) , TGFB4;LEFTA;LEFTYA;transforming growth factor;beta 4 (endometrial bleeding associated factor;LEFTY A);EBAF;Endometrial bleeding associated factor (left right determination factor A transforming growth factor beta superfamily);Endometrial bleeding associated factor;Endometrial bleeding-associated factor;LEFTY 2;TGF-beta-4;protein lefty-2;protein lefty-A;left-right determination factor A;transforming growth factor beta-4;TGFB4
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- HEK293
- E.coli
- Mammalian Cells
- Human Cells
- Fc
- His
- Non
- Myc
- Avi
Involved Pathway
LEFTY2 involved in several pathways and played different roles in them. We selected most pathways LEFTY2 participated on our site, such as TGF-beta signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEFTY2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TGF-beta signaling pathway | ID4,THBS1,RPS6KB1,SMAD7,TGFB2,ID3,GDF6,SMAD6,RBL1,NOG2 |
| Signaling pathways regulating pluripotency of stem cells | SMAD1,MAPK1,GRB2,MAP2K1,AXIN1,WNT4,WNT7B,PCGF5,Fzd4,ACVR2A |
Protein Function
LEFTY2 has several biochemical functions, for example, cytokine activity,growth factor activity,transforming growth factor beta receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LEFTY2 itself. We selected most functions LEFTY2 had, and list some proteins which have the same functions with LEFTY2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transforming growth factor beta receptor binding | TGFB1A,MSTNB,LFT1,INHBE,BMP3,INHBC,NODAL,SMURF2,NDR1,GDF2 |
| growth factor activity | FGF8,TGFB1A,FGF22,BMP7A,AMBN,NRG4,IL4,TGFB2,ENDOU,FGF21 |
| cytokine activity | IL21,IL1A,CSF1B,TNFSF13,IFNG1-2,IL20,CD70,Ifna11,GREM1A,FAM3C |
Interacting Protein
LEFTY2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEFTY2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEFTY2.
MAPK8IP2;ACSS3
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References
- Fresques, T; Zazueta-Novoa, V; et al. Selective Accumulation of Germ- Line Associated Gene Products in Early Development of the Sea Star and Distinct Differences From Germ- Line Development in the Sea Urchin. DEVELOPMENTAL DYNAMICS 243:568-587(2014).
- Chen, LY; Austin, E; et al. A Common Variant in the Left-Right Determination Factor 2 Gene (LEFTY2) Interacts With Advancing Age to Modify the Risk of Atrial Fibrillation: The Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health Study (CHS). CIRCULATION 128:-(2013).
