LEF1

  • Official Full Name

    lymphoid enhancer-binding factor 1

  • Overview

    This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

  • Synonyms

    LEF1;lymphoid enhancer-binding factor 1;LEF-1;TCF10;TCF7L3;TCF1ALPHA;TCF1-alpha;T cell-specific transcription factor 1-alpha

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • GST
  • Avi&Fc&His
Cat.# Product name Source (Host) Species Tag Protein Length Price
LEF1-540H Recombinant Human LEF1, His-tagged E.coli Human His 1-399aa
LEF1-166H Recombinant Human LEF1 protein, His-tagged E.coli Human His
LEF1-3373R Recombinant Rat LEF1 Protein Mammalian Cells Rat His
LEF1-6571C Recombinant Chicken LEF1 Mammalian Cells Chicken His
LEF1-8995Z Recombinant Zebrafish LEF1 Mammalian Cells Zebrafish His
LEF1-9035M Recombinant Mouse LEF1 Protein Mammalian Cells Mouse His
LEF1-4778HCL Recombinant Human LEF1 293 Cell Lysate HEK293 Human Non
LEF1-301549H Recombinant Human LEF1 protein, GST-tagged E.coli Human GST Met1-Asp98
LEF1-3029R Recombinant Rat LEF1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
LEF1-3029R-B Recombinant Rat LEF1 Protein Pre-coupled Magnetic Beads HEK293 Rat
LEF1-4817H Recombinant Human LEF1 Protein (Glu45-His260), N-His tagged E.coli Human His Glu45-His260
LEF1-5032M Recombinant Mouse LEF1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
LEF1-5032M-B Recombinant Mouse LEF1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    LEF1 involved in several pathways and played different roles in them. We selected most pathways LEF1 participated on our site, such as Wnt signaling pathway,Hippo signaling pathway,Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway CAMK2G,BTRC,VANGL2,TP53,PPP3CB,DVL1B,CER1,PRKCBB,PRKACG,CTNNBIP1
    Hippo signaling pathway CCND2,WWC1,BMP5,WNT16,WNT2B,WNT8B,AXIN2,LIMD1,SMAD2,BMP6
    Colorectal cancer PIK3CB,AXIN2,TGFB1,TGFB3,PIK3R5,TGFBR1,SMAD4,BRAF,CASP9,MAPK10
    Prostate Cancer IKBKB,PIK3R1,CCND1,Pdgfa&Pdgfb,GSTP1,NKX3,CREB3L1,NRAS,EP300,Ar
    Pathways in cancer Ar,PLD1,ITGA2,PTGER3,GLI2,FIGF,LPAR6,IL6,CXCL12,WNT7B
    Basal cell carcinoma GSK3B,STK36,AXIN1,FZD3,FZD9,WNT4,FZD5,SETD6,WNT8B,TCF7L2
    Acute myeloid leukemia IKBKB,ARAF,PPARD,MTOR,AKT3,AKT1,IKBKG,CEBPA,RUNX1T1,RPS6KB1
    Thyroid cancer TRP53,NTRK1,PAX8,TFG,MAPK3,BRAF,HRAS,NRAS,MAPK1,TPM3
    Melanogenesis CALM3,PRKCB,HRAS,EDNRBA,CREB3L3,FZD9,KITLG,CREB3L2,ASIP,MITFB

    Protein Function

    LEF1 has several biochemical functions, for example, C2H2 zinc finger domain binding,DNA binding,DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by LEF1 itself. We selected most functions LEF1 had, and list some proteins which have the same functions with LEF1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding MXD1,YBX1,NFKB2,KDM6A,ZNF680,IFI16,TCF3A,NKX2-5,ZNF257,MYF6
    C2H2 zinc finger domain binding THAP7,WT1,U2AF2,GATA2,ZXDC,HMGA2,EBF1,EHMT1,EHMT2,TAF9
    transcription factor activity, sequence-specific DNA binding FOXG1A,TEAD4,ZNF550,POU2F1A,GLI3,USF2,ZFP260,TBPL2,GATAD1,IRF1A
    histone binding TBL1XR1,HIST1H4E,H3F3A,SIRT1,HIST2H4A,JAK2,PRKCBB,H2AFX,SET,PRKCB
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding BARHL1A,MYF5,ZGLP1,MAFGA,MAFBB,GATA5,MAFBA,TRPS1,STAT3,MYOD1
    chromatin binding OVOL2,CRX,ORC1L,SP100,LDB2A,PDX1,HMGA1,JUB,HIF1AB,STAG1
    transcription regulatory region DNA binding HOXA13,TCF7L1A,ATF4,ZNF335,RBBP5,TBL1X,SFPQ,CTCFL,IKZF4,DLX5
    RNA polymerase II regulatory region sequence-specific DNA binding ZNF792,MYOG,SP1,ONECUT3,NFKB1,CEBPB,RUNX3,ZSCAN2,ZNF812,LMO2
    DNA binding, bending FOXC1,GATA1,TERF1,HHEX,HMGA2,HMGB1,FOXI1,FOXD1,SRY,TOP2B

    Interacting Protein

    LEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEF1.

    CTNNB1;IGF1R;TLE1;7242199;Hdac1;AURKA;BUB1;NRAS;RB1;MLH1;MSH2;BAX

    Resources

    Research Area

    Wnt Signaling Modulators
    Transcription Factors in the Akt Pathway

    References

    • Lee, JM; Miyazawa, S; et al. Shh signaling is essential for rugae morphogenesis in mice. HISTOCHEMISTRY AND CELL BIOLOGY 136:663-675(2011).
    • Koizumi, Y; Kawashima, N; et al. Wnt11 expression in rat dental pulp and promotional effects of Wnt signaling on odontoblast differentiation. CONGENITAL ANOMALIES 53:101-108(2013).

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