LDLRAP1
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Official Full Name
low density lipoprotein receptor adaptor protein 1 -
Overview
The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. [provided by RefSeq, Jul 2008] -
Synonyms
LDLRAP1;low density lipoprotein receptor adaptor protein 1;ARH;ARH1;ARH2;FHCB1;FHCB2;low density lipoprotein receptor adapter protein 1;LDL receptor adaptor protein;autosomal recessive hypercholesterolemia protein
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- T7
- Non
- DDK
- Myc
- GST
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LDLRAP1-1396H | Recombinant Human Low Density Lipoprotein Receptor Adaptor Protein 1, His-tagged | E.coli | Human | His |
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| Ldlrap1-7874M | Recombinant Mouse Ldlrap1 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Met1~Phe308 |
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| LDLRAP1-9029M | Recombinant Mouse LDLRAP1 Protein | Mammalian Cells | Mouse | His |
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| LDLRAP1-4784HCL | Recombinant Human LDLRAP1 293 Cell Lysate | HEK293 | Human | Non |
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| Ldlrap1-005M | Recombinant Mouse Ldlrap1 Protein, MYC/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| LDLRAP1-301431H | Recombinant Human LDLRAP1 protein, GST-tagged | E.coli | Human | GST | Met1-Phe308 |
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| LDLRAP1-5026M | Recombinant Mouse LDLRAP1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| LDLRAP1-5026M-B | Recombinant Mouse LDLRAP1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
LDLRAP1 involved in several pathways and played different roles in them. We selected most pathways LDLRAP1 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with LDLRAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | DDL-2,NTRK1,WASH,IL2RG,EPN2,FAM21C,USP8,ZFYVE9,IGF2R,RAB4A |
Protein Function
LDLRAP1 has several biochemical functions, for example, AP-2 adaptor complex binding,beta-amyloid binding,clathrin adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LDLRAP1 itself. We selected most functions LDLRAP1 had, and list some proteins which have the same functions with LDLRAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| signaling adaptor activity | MPP7,SH2B2,AFAP1L2,GNB2L1,HOMER1,SH2B3,SH2B1 |
| clathrin binding | SYT10,SNAP91,PICALMA,SYT1B,SYT3,SYT11,DNER,SYT13,PICALMB,AFTPH |
| clathrin adaptor activity | ARRB1,DAB2,PICALM |
| phosphotyrosine binding | MAPK1,CBLB,STAP1,CBL,ZAP70,MAPK3,GRB2,SHC1,ACP2,CBLC |
| beta-amyloid binding | APBB2,SORL1,IDE,CHRNA7,ARMCX5-GPRASP2,HBA-A2,MAPK8IP2,APBB1,FBXO2,TGFB2 |
| AP-2 adaptor complex binding | ARRB1,OTOF,AAK1,TBC1D5,FCHO1 |
| receptor signaling complex scaffold activity | SPAG9,MAGI2,G3BP2,SHANK1,MMS19,GRIP2A,MAPK8IP3,DEDD2,CARD10,GRIP1 |
| phosphatidylinositol-4,5-bisphosphate binding | RS1,VIL1,MARK1,KCNJ1,FCHO2,ADAP2,COMMD1,JPH2,FRMPD4,KCNJ2 |
| low-density lipoprotein particle receptor binding | LRPAP1,SLC9A3R2,SACS,PCSK9,APOA5,AP2M1,HSP90B1,SYT1,DKK1,SNX17 |
Interacting Protein
LDLRAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LDLRAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LDLRAP1.
AP2B1;OBFC1;LDLR;Klc1;CLTC;Lrp2;SNW1
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References
- Yang, XV; Banerjee, Y; et al. Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106:274-279(2009).
- Gaultier, A; Arandjelovic, S; et al. Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappa B pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor. BLOOD 111:5316-5325(2008).
