LASP1
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Official Full Name
LIM and SH3 protein 1 -
Overview
Lasp-1 is an actin-binding scaffolding protein that is overexpressed in 8-12% of breast cancers and is correlated to increased incidences of metastasis. Lasp-1 localizes to newly forming focal adhesions and membrane ruffles during cell migration (Lin, 2004). -
Synonyms
LASP1;LIM and SH3 protein 1;LIM and SH3 domain protein 1;Lasp 1;MLN50;MLN 50;metastatic lymph node gene 50 protein;Lasp-1
Recombinant Proteins
- Zebrafish
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- Mammalian Cells
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
LASP1 involved in several pathways and played different roles in them. We selected most pathways LASP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LASP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
LASP1 has several biochemical functions, for example, SH3/SH2 adaptor activity,actin filament binding,ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LASP1 itself. We selected most functions LASP1 had, and list some proteins which have the same functions with LASP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ROBO1,ZMYM4,ZNF177,CDC25C,USP1,RINT1,HINFP,WDFY2,PPEF1,TRIAP1 |
| SH3/SH2 adaptor activity | SLA,CD28,GRB14,SH3BGRL,LAT,SH2D1A,SHB,HSH2D,ITSN2,STAP1 |
| actin filament binding | ANTXR1,FSCN1,DBNLB,AJUBA,MYO7A,SCIN,USH1C,SYNE2,MTSS1,MYO1E |
| ion transmembrane transporter activity | SFXN5A,GJA1,SFXN1,SFXN4,PLP2,SFXN3,S100A6,TRPV2,SFXN5B,SFXN2 |
| zinc ion binding | ZNRF2A,LIMD2,TRIM40,PDLIM4,NR1D2,TRIM39,LONRF1L,UQCRC2A,PPARG,VDR |
Interacting Protein
LASP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LASP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LASP1.
TRIP13;MDFI;TJP2;ARHGEF15
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