LAMTOR2
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Official Full Name
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 -
Overview
The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
LAMTOR2;late endosomal/lysosomal adaptor, MAPK and MTOR activator 2;roadblock domain containing 3 , ROBLD3;ragulator complex protein LAMTOR2;ENDAP;endosomal adaptor protein;MAPBPIP;MAPKSP1 adaptor protein;MAPKSP1AP;mitogen activated protein bindi
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
LAMTOR2 involved in several pathways and played different roles in them. We selected most pathways LAMTOR2 participated on our site, such as ARMS-mediated activation,Axon guidance,Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAMTOR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | RHOAE,CTNNA2,LIN28A,TRIO,ARPC1B,DUSP6,MED21,RASGRP1,MED18,ADAM22 |
| Downstream signal transduction | AGO3,PAQR3B,TRAT1,SPTBN1,PAQR3A,FGF8B,FGFR1B,JAK1,SPRED1,SPRED2 |
| DAP12 signaling | FGF8B,SPRED2,FGFR1B,MARK3,FRS2,SPTBN2,AGO3,AGO1,WDR83,SPNA1 |
| DAP12 interactions | SPNA1,RASGRP4,JAK3,SPRED2,AHCYL1,PEBP1,AGO2,DUSP6,CSF2RA,WDR83 |
| Cytokine Signaling in Immune system | IFIT12,IRF9,IRAK3,TRIM6,IFIT14,KLB,EDA,CSF2,GBP5,OASL |
| Cellular responses to stress | HIRA,PHC1,POT1,TERF1,ASF1A,EHMT2,HBXIP,HIST2H3C,DYNLL2B,AMBRA1A |
| Axon guidance | COL9A1A,SPTBN2,LRRC4,DNM1,COL6A1,FRS2,DUSP7,TRIO,EPHB4A,DUSP6 |
| ARMS-mediated activation | SPRED2,NEFLB,DUSP5,FGF10B,SPNA1,CRK,DUSP1,SPTA1,RASGRP1,EGF |
Protein Function
LAMTOR2 has several biochemical functions, for example, contributes_to guanyl-nucleotide exchange factor activity,protein binding,contributes_to protein complex scaffold. Some of the functions are cooperated with other proteins, some of the functions could acted by LAMTOR2 itself. We selected most functions LAMTOR2 had, and list some proteins which have the same functions with LAMTOR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to protein complex scaffold | LAMTOR3,C7orf59,HBXIP,LAMTOR1 |
| contributes_to guanyl-nucleotide exchange factor activity | C7orf59,ALS2,LAMTOR1,EIF2B4,EIF2B1,EIF2B3,HBXIP,LAMTOR3,EIF2B5,EIF2B2 |
| protein binding | HGS,PRPSAP1,Tnfrsf22,NME5,BTC,SP1,SRSF1,DGCR6L,GAS7,ADRB1 |
Interacting Protein
LAMTOR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAMTOR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAMTOR2.
LAMTOR3;LAMTOR1
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References
- Sparber, F; Tripp, CH; et al. The Late Endosomal Adaptor Molecule p14 (LAMTOR2) Regulates TGF beta 1-Mediated Homeostasis of Langerhans Cells. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:119-129(2015).
- Fichera, M; Barone, R; et al. Familial 1q22 microduplication associated with psychiatric disorders, intellectual disability and late-onset autoimmune inflammatory response. MOLECULAR CYTOGENETICS 7:-(2014).
