LAGE3
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Official Full Name
L antigen family, member 3 -
Overview
This gene belongs to the ESO/LAGE gene family, members of which are clustered together on chromosome Xq28, and have similar exon-intron structures. Unlike the other family members which are normally expressed only in testis and activated in a wide range of human tumors, this gene is ubiquitously expressed in somatic tissues. The latter, combined with the finding that it is highly conserved in mouse and rat, suggests that the encoded protein is functionally important. An intronless pseudogene with high sequence similarity to this gene is located on chromosome 9. -
Synonyms
LAGE3;L antigen family, member 3;L antigen family member 3;CVG5;DNA segment on chromosome X (unique) 9879 expressed sequence;DXS9879E;DXS9951E;ESO3;ITBA2;protein ESO-3
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LAGE3-493H | Recombinant Human LAGE3, His-tagged | E.coli | Human | His | 1-143aa | |
| LAGE3-528H | Recombinant Human L antigen family, member 3, His-tagged | E.coli | Human | His | 1-143 a.a. |
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| LAGE3-8926M | Recombinant Mouse LAGE3 Protein | Mammalian Cells | Mouse | His |
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| LAGE3-167H | Recombinant Human LAGE3 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| Lage3-3747M | Recombinant Mouse Lage3 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| LAGE3-4978M | Recombinant Mouse LAGE3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| LAGE3-4978M-B | Recombinant Mouse LAGE3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
LAGE3 involved in several pathways and played different roles in them. We selected most pathways LAGE3 participated on our site, such as Gene Expression,tRNA modification in the nucleus and cytosol,tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAGE3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| tRNA processing | TSEN54,KIAA1456,LBH,ADAT3,TYW3,PUS1,FAM98B,TRMT6,C2orf49,TRMT12 |
| tRNA modification in the nucleus and cytosol | TRDMT1,CDKAL1,MANEA,TRMT44,METTL1,TRMT11,ADAT1,CCDC76,TYW1,LBH |
| Gene Expression | ZNF550,NR1D2,SAP30L,DGCR8,ZNF729,NRBP1,ZNF713,EEF1D,DNMT3A,ZNF706 |
Protein Function
LAGE3 has several biochemical functions, for example, molecular_function,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LAGE3 itself. We selected most functions LAGE3 had, and list some proteins which have the same functions with LAGE3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CAND2,FBXW9,CYBRD1,BRAT1,PCM1,BUD13,KAL1,UBAP2L,MED16,FOXC2 |
| molecular_function | SELM,CRYGM2D17,TLE4,FAM65C,MAGEA8,ASB13A.1,VSTM2B,SERHL,AMDHD1,PRR15LA |
Interacting Protein
LAGE3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAGE3 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAGE3.
PDE9A;KRT40;HLA-B;SQSTM1;IKBKE;OSGEP;PTBP3;P;Osgep;TP53RK
Resources
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References
- Cramer, DW; O'Rourke, DJ; et al. CA125 Immune Complexes in Ovarian Cancer Patients with Low CA125 Concentrations. CLINICAL CHEMISTRY 56:1889-1892(2010).
- Choi, SI; Kim, SY; et al. TM4SF4 overexpression in radiation-resistant lung carcinoma cells activates IGF1R via elevation of IGF1. ONCOTARGET 5:9823-9837(2014).
