KYNU
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Official Full Name
kynureninase -
Overview
Kynureninase is a pyridoxal-5-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. -
Synonyms
KYNU;kynureninase;kynureninase (L kynurenine hydrolase);L kynurenine hydrolase;kynureninase (L-kynurenine hydrolase);L-kynurenine hydrolase;OTTHUMP00000162647;OTTHUMP00000204304;OTTHUMP00000204305;4432411A05Rik
Recombinant Proteins
- Human
- Mouse
- Rat
- Sf21 Cells
- Insect Cells
- Mammalian Cells
- HEK293
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
KYNU involved in several pathways and played different roles in them. We selected most pathways KYNU participated on our site, such as Tryptophan metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with KYNU were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | PCYT1AB,ST3GAL3B,ACSL3,GCH1,ACSL5,MAOA,RIMKLA,PPT2,NANSA,TRIT1 |
| Tryptophan metabolism | CYP4F12,TDO2A,RNF25,HADHA,AOX3,TDO2,MAOA,AANAT1,ALDH9A1A.1,GCDH |
Protein Function
KYNU has several biochemical functions, for example, kynureninase activity,protein homodimerization activity,pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KYNU itself. We selected most functions KYNU had, and list some proteins which have the same functions with KYNU. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| pyridoxal phosphate binding | PYGB,TAT,CCBL2,SPTLC1,AADAT,ACCS,CBSB,CCBL1,AGXT2L2,CBSA |
| protein homodimerization activity | MID2,TG,IDE,INHBB,HRSP12,GRIK2,GPD1A,ENG,TBX15,IL6R |
Interacting Protein
KYNU has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KYNU here. Most of them are supplied by our site. Hope this information will be useful for your research of KYNU.
nhaA;ere_dna;RET
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