KRT8
-
Official Full Name
keratin 8 -
Overview
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] -
Synonyms
KRT8;keratin 8;K8;KO;CK8;CK-8;CYK8;K2C8;CARD2;keratin, type II cytoskeletal 8;cytokeratin 8;cytokeratin-8;type-II keratin Kb8
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Rhesus macaque
- Mouse
- Bovine
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- bovine liver
- Insect Cell
- Wheat Germ
- In Vitro Cell Free System
- Mammalian cells
- Non
- His
- His&S
- His&Fc&Avi
- Myc&DDK
- His&Myc
- GST
- His&SUMO
- Flag
Involved Pathway
KRT8 involved in several pathways and played different roles in them. We selected most pathways KRT8 participated on our site, such as EGFR1 Signaling Pathway,Signaling mediated by p38-alpha and p38-beta, which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling mediated by p38-alpha and p38-beta | USF1,HBP1,GDI1 |
| EGFR1 Signaling Pathway | TNK2,EPS8,ERRFI1,SH3BGRL,USP6NL,KRT7,CEBPA,APPL2,DNM1,PTK6 |
Protein Function
KRT8 has several biochemical functions, for example, protein binding,protein complex binding,scaffold protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT8 itself. We selected most functions KRT8 had, and list some proteins which have the same functions with KRT8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| scaffold protein binding | MDM2,MAP2K2,SHANK1,GRID2,KCNH2,CRIPT,CACNA1G,CASP8,NOS3,P2RY1 |
| protein binding | MEGF6,ZFP64,PDCD10,FGF3,UGGT2,UPF1,NITR9,FXR2,TAGLN2,ARHGAP33 |
| protein complex binding | PCSK2,MTHFR,ADRB2,CD2AP,THRA,RAP1A,HNF1B,TULP2,KAT2B,CEBPA |
| structural molecule activity | SEPT7,TUBG2,MAP4,PGM5,TUBB5,VCLA,CLDN1,KRT86,EIF3A,CLTB |
Interacting Protein
KRT8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT8 here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT8.
KRT18;CFTR;p27958-pro_0000037566
Resources
Related Services
Related Products
References
- Zhou, Y; Hu, ZQ; et al. Genome-Wide Demethylation by 5-aza-2 '-Deoxycytidine Alters the Cell Fate of Stem/Progenitor Cells. STEM CELL REVIEWS AND REPORTS 11:87-95(2015).
- Bunel, A; Jorssen, EP; et al. Individual bovine in vitro embryo production and cumulus cell transcriptomic analysis to distinguish cumulus-oocyte complexes with high or low developmental potential. THERIOGENOLOGY 83:228-237(2015).
