KRT4
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Official Full Name
keratin 4 -
Overview
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. -
Synonyms
KRT4;keratin 4;CYK4;keratin, type II cytoskeletal 4;CK4;cytokeratin 4;K4;keratin;type II cytoskeletal 4;type-II keratin Kb4;CK-4;FLJ31692
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- Yeast
- HEK293
- His
- His&S
- GST
- Non
- His&Fc&Avi
- His&SUMO
Involved Pathway
KRT4 involved in several pathways and played different roles in them. We selected most pathways KRT4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
KRT4 has several biochemical functions, for example, protein binding,structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT4 itself. We selected most functions KRT4 had, and list some proteins which have the same functions with KRT4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural molecule activity | SEMG2,NPHP1,KRTAP3-3,MPZ,INAA,CLDNE,LAMA3,COL4A3,ADD1,CLDN11 |
| protein binding | HAUS1,CNTROB,RAB2A,FGB,DUSP21,RPP25L,MEAF6,LHX9,C19orf73,BATF2 |
Interacting Protein
KRT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT4.
KRT13;KRT38;tax;KRT15;KRT33B;KRT40;USP1;UCHL1
Resources
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References
- Sawanobori, Y; Ueta, H; et al. Three Distinct Subsets of Thymic Epithelial Cells in Rats and Mice Defined by Novel Antibodies. PLOS ONE 9:-(2014).
- Nayak, AP; Hettick, JM; et al. Toluene Diisocyanate (TDI) Disposition and Co-Localization of Immune Cells in Hair Follicles. TOXICOLOGICAL SCIENCES 140:327-337(2014).
