KPNB1
-
Official Full Name
karyopherin (importin) beta 1 -
Overview
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013] -
Synonyms
KPNB1;karyopherin (importin) beta 1;IMB1;IPO1;IPOB;Impnb;NTF97;importin subunit beta-1;PTAC97;importin 1;importin 90;importin-90;nuclear factor p97;importin beta-1 subunit;karyopherin subunit beta-1;pore targeting complex 97 kDa subunit
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- Sf9 Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Flag
- His&Fc&Avi
- GST
Involved Pathway
KPNB1 involved in several pathways and played different roles in them. We selected most pathways KPNB1 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with KPNB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | SENP2,EIF3BA,AAAS,ELAC1,RPP38,RPP40,SNUPN,EIF4E2RS1,PABPC4,SUMO2B |
Protein Function
KPNB1 has several biochemical functions, for example, Ran GTPase binding,enzyme binding,nuclear localization sequence binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KPNB1 itself. We selected most functions KPNB1 had, and list some proteins which have the same functions with KPNB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Ran GTPase binding | BIRC5,IPO13,RANGRF,IPO8,RANBP2,TNPO1,TNPO2,RANBP10,NUP153,XPOT |
| poly(A) RNA binding | TPT1,AKAP8,DDX42,DROSHA,RPS16,FAM32A,RC3H2,POLR2A,DHX15,PNPT1 |
| protein domain specific binding | SNCA,SORBS2,HOXB1,ARRB2,RQCD1,CRB3,HIST1H4B,TUBB,CALM3,NR0B1 |
| zinc ion binding | POLR2K,RNF145B,PPARAA,SEC24D,CA13,DZIP3,RNF122,ADH5,RNF222,PDZRN3 |
| protein binding | DEDD,TUBGCP3,DDL-2,ECE1,DDX21,AGRN,EPM2AIP1,HIF1A,ERO1L,TSEN54 |
| protein transporter activity | RAP1A,TNPO1,RAMP2,KPNA2,RANGRF,VPS26BL,VPS26A,COX18,KPNA1,L7RN6 |
| nuclear localization sequence binding | BRAP,KPNA4,TNPO1,KPNA1,KPNA3,NUP214,RANBP6,KPNA5,IPO13,NFKBIA |
| enzyme binding | BACE1,C6orf211,ATG3,SCNM1-PS,HNRNPUL1,PPP3CA,LAMB1,PICK1,CBX3,NOXO1 |
Interacting Protein
KPNB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KPNB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KPNB1.
KPNA2;L1;NSP1;PLCD1;Mkl1;rev;ERBB2
Resources
Related Services
Related Products
References
