KPNA4
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Official Full Name
karyopherin alpha 4 (importin alpha 3) -
Overview
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. -
Synonyms
KPNA4;karyopherin alpha 4 (importin alpha 3);importin subunit alpha-4;IPOA3;MGC12217;MGC26703;QIP1;SRP3;importin alpha Q1;karyopherin subunit alpha-4;FLJ31113
Recombinant Proteins
- Zebrafish
- Chicken
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- His&GST
- Flag
- Myc&DDK
Involved Pathway
KPNA4 involved in several pathways and played different roles in them. We selected most pathways KPNA4 participated on our site, such as Antiviral mechanism by IFN-stimulated genes,Cytokine Signaling in Immune system,Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with KPNA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Infectious disease | AP1G1,CPSF4,RCC1,DOCK2,PACS1,LTF,KPNA3,EEF2,ANTXR1,NMT2 |
| Antiviral mechanism by IFN-stimulated genes | NUP50,IFIT14,IFIT8,EIF4G2A,EIF4G1,EIF4G2,IFIT10,KPNA5,ARIH1,MX2 |
| Disease | MMAA,EEF2,RBP4,TAF1L,HDAC6,TICAM1,TH1L,TCEA1,CYP11A1,NA |
| Influenza Infection | CPSF4,IPO5,KPNA5,KPNA3 |
| Cytokine Signaling in Immune system | CASPBL,TRIM6,IL1RN,IFI27,EIF4G2,GBP1,RASGRP4,ARIH1,EDA,EGR1 |
| Host Interactions with Influenza Factors | KPNA5,CPSF4,KPNA3 |
| ISG15 antiviral mechanism | HERC5,ARIH1,EIF4G2A,USP18,IFIT8,IFIT11,KPNA3,ARIH1L,IFIT14,IFIT10 |
| Immune System | CTSLL,PAG1,KLHL21,PELI1,KLRF1,TXNIPA,AMICA1,WASF3,RNF220,BTR29 |
Protein Function
KPNA4 has several biochemical functions, for example, nuclear localization sequence binding,protein binding,protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KPNA4 itself. We selected most functions KPNA4 had, and list some proteins which have the same functions with KPNA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein transporter activity | KPNA5,RANGRF,SNUPN,AP2S1,PGAP2,KPNA6,AP1G2,VPS26A,ITGB1BP1,KPNA3 |
| protein binding | IFNA2,RAD1,CARKD,EDDM3B,ATPAF1,SPINK7,HSPA13,ZNF26,CCL11,MXD1 |
| nuclear localization sequence binding | KPNA6,IPO4,KPNB1,TNPO1,RANBP6,IPO13,KPNA3,IPO5,KPNA2,KPNA1 |
Interacting Protein
KPNA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KPNA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KPNA4.
gag-pol;HNRNPC;CYHR1;Ranbp2;MAT2B;NUP50;PLAA
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References
- Arjomand, A; Baker, MA; et al. The alpha-importome of mammalian germ cell maturation provides novel insights for importin biology. FASEB JOURNAL 28:3480-3493(2014).
- Whiley, PAF; Miyamoto, Y; et al. Changing subcellular localization of nuclear transport factors during human spermatogenesis. INTERNATIONAL JOURNAL OF ANDROLOGY 35:158-169(2012).
