KLK5
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Official Full Name
kallikrein-related peptidase 5 -
Overview
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] -
Synonyms
KLK5;kallikrein-related peptidase 5;SCTE;KLKL2;KLK-L2;kallikrein-5;kallikrein 5;kallikrein-like protein 2;stratum corneum tryptic enzyme
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Mammalian cells
- CHO
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
KLK5 involved in several pathways and played different roles in them. We selected most pathways KLK5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KLK5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
KLK5 has several biochemical functions, for example, peptidase activity,protein binding,serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLK5 itself. We selected most functions KLK5 had, and list some proteins which have the same functions with KLK5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TEX264,OSTC,AP2A1,CSTF3,MRM1,PURA,ARFGAP3,SHISA3,NPRL2,MATN3 |
| serine-type peptidase activity | GM5077,TPSAB1,DPP6B,Gzmd,ENDOU,DPP10,TRY,Gzmg,TMPRSS4A,MCPT8 |
| peptidase activity | KLK1B1,ADAMTS16,CTSL.1,F2RL1.1,UFSP2,PCSK5B,SPCS1,KEX2,Shh,Adamts19 |
| serine-type endopeptidase activity | CFD,ST14A,KLK1B1,LTF,KLK11,TPSAB1,GZMB,PRSS42,MCPT8,F9 |
Interacting Protein
KLK5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLK5 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLK5.
FLG;AURKA;BAG4;TGFB1;ESR1;ERBB2;IGF1R;NOTCH2;CASP8;TSG101
Resources
Research Area
Serine Proteases and RegulatorsFibrinolysis System
Plasmin/Plasminogen and Kallikrein/Kinin Systems
Related Services
Related Products
References
- Sperrhacke, M; Fischer, J; et al. SPINK9 Stimulates Metalloprotease/EGFR-Dependent Keratinocyte Migration via Purinergic Receptor Activation. JOURNAL OF INVESTIGATIVE DERMATOLOGY 134:1645-1654(2014).
- Fortugno, P; Bresciani, A; et al. Proteolytic Activation Cascade of the Netherton Syndrome-Defective Protein, LEKTI, in the Epidermis: Implications for Skin Homeostasis. JOURNAL OF INVESTIGATIVE DERMATOLOGY 131:2223-2232(2011).
