KLHL13
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Official Full Name
kelch-like 13 (Drosophila) -
Overview
This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. -
Synonyms
KLHL13;kelch-like 13 (Drosophila);BKLHD2, BTB and kelch domain containing 2, KIAA1309 , KIAA1309;kelch-like protein 13;FLJ10262;BKLHD2;BTB and kelch domain containing 2;BTB and kelch domain containing 2 KIAA1309;BTB and kelch domain containing protein 2;Kelch like 13 (Drosophila);Kelch like protein 13;KIAA1309;MGC74791;OTTHUMP00000023881;OTTHUMP00000023882;OTTHUMP00000023883;OTTHUMP00000023885;OTTHUMP00000215715
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KLHL13-412H | Recombinant Human KLHL13, GST-tagged | E.coli | Human | GST | C-169aa | |
| KLHL13-2788C | Recombinant Chicken KLHL13 | Mammalian Cells | Chicken | His |
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| KLHL13-5734Z | Recombinant Zebrafish KLHL13 | Mammalian Cells | Zebrafish | His |
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| KLHL13-8061Z | Recombinant Zebrafish KLHL13 | Mammalian Cells | Zebrafish | His |
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| KLHL13-8705M | Recombinant Mouse KLHL13 Protein | Mammalian Cells | Mouse | His |
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| KLHL13-4912HCL | Recombinant Human KLHL13 293 Cell Lysate | HEK293 | Human | Non |
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| Klhl13-3710M | Recombinant Mouse Klhl13 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| KLHL13-4265H | Recombinant Human KLHL13 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| KLHL13-4852M | Recombinant Mouse KLHL13 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| KLHL13-4852M-B | Recombinant Mouse KLHL13 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
KLHL13 involved in several pathways and played different roles in them. We selected most pathways KLHL13 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLHL13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | PRP19,SIAH1,RHOBTB2,UBE2O,RFWD2,PIAS2,RNF7,UBE2D4,UBE2D3,UBE2IB |
Protein Function
KLHL13 has several biochemical functions, for example, contributes_to ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLHL13 itself. We selected most functions KLHL13 had, and list some proteins which have the same functions with KLHL13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ubiquitin-protein transferase activity | ANAPC11,KLHL5,KLHL17,KLHL4,TCEB3B,KLHL38,KEAP1B,RNF20,TCEB3,TNFAIP1 |
Interacting Protein
KLHL13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLHL13 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLHL13.
ZMYM6;HSP90AB1;USP11;COPS2;MAD2L1;KLHL22;ZMYM4;COPS6;NUDCD3;COPS5;COPS4;KLHL9;UBXN7
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