KIR3DL2
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Official Full Name
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 -
Overview
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
KIR3DL2;killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2;killer cell immunoglobulin-like receptor 3DL2;CD158K;cl 5;nkat4;nkat4a;nkat4b;CD158 antigen like family member K;CD158 antigen-like family member K;KI3L2_HUMAN;Killer cell immunoglobulin like receptor 3DL2;killer cell immunoglobulin like receptor KIR3DL2;Killer cell immunoglobulin like receptor, three domains, long cytoplasmic tail, 2;KIR antigen 3DL2;Kirl2;MHC class I NK cell receptor;Natural killer associated transcript 4;natural killer cell inhibitory receptor;Natural killer-associated transcript 4;NK associated transcript 4;NK associated transcript 4A, included;NK associated transcript 4B, included;NKAT-4;p140;p70 natural killer cell receptor clone CL 5;p70 natural killer cell receptor clone CL-5;p70 NK receptor CL 5;p70 NK receptor CL-5;killer Ig receptor;p70 killer cell inhibitory receptor;killer cell immunoglobulin-like receptor KIR3DL2
Recombinant Proteins
- Human
- Rhesus macaque
- Mammalian Cells
- C-His
- E.coli
- HEK293
- Insect Cells
- Fc
- GST&His
- His
- Non
- Avi&Fc&His
- Fc&His
- Avi&His
Involved Pathway
KIR3DL2 involved in several pathways and played different roles in them. We selected most pathways KIR3DL2 participated on our site, such as Antigen processing and presentation,Natural killer cell mediated cytotoxicity,Graft-versus-host disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIR3DL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Graft-versus-host disease | HLA-DQB1,HLA-DQA1,CD86,H2-Q10,HLA-A,HLA-C,KLRC1,TNF,HLA-DRB3,Fasl |
| Antigen processing and presentation | KIR2DS5,CTSL1,CD8B1,NFYC,HSPA5,KLRC3,KIR2DL4,TAPBP,KIR2DS4,HSPA1B |
| Natural killer cell mediated cytotoxicity | ULBP1,KLRD1,NCR2,IFNA8,ULBP2,PTPN6,KIR2DL4,ULBP3,HLA-A,RAC2 |
Protein Function
KIR3DL2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by KIR3DL2 itself. We selected most functions KIR3DL2 had, and list some proteins which have the same functions with KIR3DL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
KIR3DL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIR3DL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KIR3DL2.
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References
- Marie-Cardine, A; Viaud, N; et al. IPH4102, a Humanized KIR3DL2 Antibody with Potent Activity against Cutaneous T-cell Lymphoma. CANCER RESEARCH 74:6060-6070(2014).
- Viaud, N; Granier, N; et al. Novel therapeutic and diagnostic antibodies against KIR3DL2, a unique tumor antigen overexpressed on subtypes of T Cell Lymphomas. CANCER RESEARCH 73:-(2013).
