KHSRP
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Official Full Name
KH-type splicing regulatory protein -
Overview
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including;transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 (PubMed 9136930); Gherzi et al.,;2004 (PubMed 15175153)). -
Synonyms
KHSRP;KH-type splicing regulatory protein;far upstream element-binding protein 2;FBP2;FUBP2;FUSE binding protein 2;KSRP;p75;FUSE-binding protein 2;KH type-splicing regulatory protein;MGC99676
Recombinant Proteins
- Rat
- Zebrafish
- Chicken
- Mouse
- Human
- Mammalian Cells
- HEK293
- Wheat Germ
- E.coli
- His
- DDK
- Myc
- GST
- Flag
- Avi
- Fc
Involved Pathway
KHSRP involved in several pathways and played different roles in them. We selected most pathways KHSRP participated on our site, such as Gene Expression,KSRP (KHSRP) binds and destabilizes mRNA,Regulation of mRNA stability by proteins that bind AU-rich elements, which may be useful for your reference. Also, other proteins which involved in the same pathway with KHSRP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | NR5A1,GTF3A,SUPT16H,ZNF398,CLNS1A,YAP1,ZNF556,PHF1,THOC4,ZNF180 |
| KSRP (KHSRP) binds and destabilizes mRNA | DCP2,EXOSC8 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | ZFP36L1B,HUG,SETB,SETA,TNPO1,HNRNPD,ANP32A,SET,ELAVL1,ZFP36L1 |
Protein Function
KHSRP has several biochemical functions, for example, DNA binding,RNA binding,mRNA 3-UTR binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KHSRP itself. We selected most functions KHSRP had, and list some proteins which have the same functions with KHSRP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mRNA binding | SRSF1,TPR,CSTF3,RBFOX3,XPO5,RBMX,HNRNPAB,RPS26L,CLUHA,RBM4 |
| DNA binding | MEF2CB,SALL1,ZNF426,CTCFL,ZBED2,YBX1,DEK,SRY,TCEA1,EBF2 |
| nucleic acid binding | BCL6AB,PRDM1A,PTBP2B,CIRBPA,PTBP1B,RNASEL2,ZBTB2A,ZFP35,ZFP521,GTF3AB |
| RNA binding | DNMT1,SF3B3,CNBPA,HNRNPAB,IREB2,EIF4G1A,CNOT6,NIFK,KIAA0907,KIN |
| poly(A) RNA binding | RPS15,NOVA1,SAMD4B,CSDA,SCAF4,G3BP2,C1orf53,PUF60,NOP58,MAPRE1 |
| mRNA 3-UTR binding | ELAVL1,PPP1R2P9,RNF20,SERBP1,RBM24,CARHSP1,IGF2BP3,PARN,RNPS1,HNRNPC |
Interacting Protein
KHSRP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KHSRP here. Most of them are supplied by our site. Hope this information will be useful for your research of KHSRP.
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References
- Kirsten, A; Beck, S; et al. New Autoantibodies in pediatric opsocionus-myoclonus syndrome. AUTOIMMUNITY, PT B: NOVEL APPLICATIONS OF BASIC RESEARCH 1110:256-260(2007).
