KCNN3
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Official Full Name
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 -
Overview
KCNN3 forms one of several calcium-activated potassium channels which are activated in a voltage-independent manner and have a relatively small unit conductance and high sensitivity to intracellular calcium. Activation is followed by membrane hyperpolariz -
Synonyms
KCNN3;potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3;small conductance calcium-activated potassium channel protein 3;hSK3;KCa2.3;SKCA3;SKCa 3;SK3
Recombinant Proteins
- Human
- Rat
- Mus musculus
- Sus scrofa (Pig)
- Wheat Germ
- Mammalian Cells
- HEK293
- E.coli
- Non
- His
- His&Fc&Avi
Involved Pathway
KCNN3 involved in several pathways and played different roles in them. We selected most pathways KCNN3 participated on our site, such as Ca2+ activated K+ channels,Insulin secretion,Neuronal System, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Potassium Channels | KCNJ1B,KCNH6,KCNC1,KCNK2,KCNA5,DDX1,KCNJ1A.4,KCNJ1A.3,KCNH2,KCNK1A |
| Ca2+ activated K+ channels | KCNMB2,KCNN4,KCNMB1,KCNN1,KCNN2,KCNN1A,KCNN1B,KCNMA1 |
| Insulin secretion | KCNMB1,GPR119,KCNMA1,SLC2A1,Adcy4,PRKACA,RIMS2,STX1A,ADCYAP1,PCLO |
| Neuronal System | KCNK13B,BZRAP1,SLC18A3A,PANX1A,KCNK10B,SLC1A7B,ABCC9,KCNMA1,GJA10,KCNJ1A.4 |
Protein Function
KCNN3 has several biochemical functions, for example, calmodulin binding,small conductance calcium-activated potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNN3 itself. We selected most functions KCNN3 had, and list some proteins which have the same functions with KCNN3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | ORAI1,MYH1B,TTN,OBSCN,GRIN1,ATPIF1,NRGN,PHKA1,ITPKC,CAMK2G |
| small conductance calcium-activated potassium channel activity | KCNN2,KCNN1B,KCNN1A,KCNN1 |
Interacting Protein
KCNN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNN3.
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