KCNN1
-
Official Full Name
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 -
Overview
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. -
Synonyms
KCNN1;potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1;small conductance calcium-activated potassium channel protein 1;hSK1;KCa2.1;KCNN 1;KCNN1_HUMAN;SK;SK1;SKCa 1;SKCa1;Small conductance calcium activated potassium channel protein 1
Recombinant Proteins
- Human
- Rat
- Mouse
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- His&Fc&Avi
Involved Pathway
KCNN1 involved in several pathways and played different roles in them. We selected most pathways KCNN1 participated on our site, such as Ca2+ activated K+ channels,Insulin secretion,Neuronal System, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuronal System | SNAP25A,KCNA10,PANX1,KCNN3,ARL6IP5B,PANX1B,CPLX1,KCNS3,KCNJ1,SLC6A12 |
| Insulin secretion | ITPR3,PRKCG,CREB5,KCNMB2,CREB3L1,KCNN4,SNAP25,KCNMB3,ATP1B1,Adcy4 |
| Potassium Channels | KCNG1,KCNJ1,KCNAB2,KCNK13B,KCNA2B,KCNH8,KCNMB1,KCNG3,KCNA5,KCNH6A |
| Ca2+ activated K+ channels | KCNN1B,KCNN3,KCNMB1,KCNN1A,KCNMB2,KCNN2,KCNMA1,KCNN4 |
Protein Function
KCNN1 has several biochemical functions, for example, calcium-activated potassium channel activity,calmodulin binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNN1 itself. We selected most functions KCNN1 had, and list some proteins which have the same functions with KCNN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| small conductance calcium-activated potassium channel activity | KCNN1B,KCNN2,KCNN1A,KCNN3 |
| protein heterodimerization activity | AOC3,PANX1,UGT1A3,CHRAC1,BTBD11A,HIST1H2AG,PPP2R1A,ATF4,UBA3,CENPW |
| calmodulin binding | CNGA2,DAPK2,IQGAP3,CAMKK1,CNN2,SLC8A2,MAPKAPK2A,MYO3A,CAMKV,NOS1 |
| calcium-activated potassium channel activity | KCNMB3,KCNMA1,KCNMB1,KCNMB4,KCNT1,KCNN1A,PKD2L1,HPN,KCNK18,CCT8L2 |
Interacting Protein
KCNN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNN1.
GRB2
Resources
Related Services
Related Products
References
- Kim, JJ; Park, YM; et al. Identification of KCNN2 as a susceptibility locus for coronary artery aneurysms in Kawasaki disease using genome-wide association analysis. JOURNAL OF HUMAN GENETICS 58:521-525(2013).
- Chang, SH; Chang, SN; et al. Significant Association of rs13376333 in KCNN3 on Chromosome 1q21 With Atrial Fibrillation in a Taiwanese Population. CIRCULATION JOURNAL 76:184-188(2012).
- Li, C; Wang, F; et al. Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GeneID population. HUMAN GENETICS 129:239-246(2011).
- Mauler, F; Hinz, V; et al. Selective intermediate-/small-conductance calcium-activated potassium channel (KCNN4) blockers are potent and effective therapeutics in experimental brain oedema and traumatic brain injury caused by acute subdural haematoma. EUROPEAN JOURNAL OF NEUROSCIENCE 20:1761-1768(2004).
