KCNK18
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Official Full Name
potassium channel, subfamily K, member 18 -
Overview
Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains and the encoded protein functions as an outward rectifying potassium channel. A mutation in this gene has been found to be associated with migraine with aura.[provided by RefSeq, Jan 2011] -
Synonyms
KCNK18;potassium channel, subfamily K, member 18;TRIK;MGR13;TRESK;TRESK2;K2p18.1;TRESK-2;potassium channel subfamily K member 18;TWIK-related individual K+ channel;TWIK-related spinal cord K+ channel;TWIK-related individual potassium channel;TWIK-related spinal cord potassium channel
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
KCNK18 involved in several pathways and played different roles in them. We selected most pathways KCNK18 participated on our site, such as Neuronal System,Potassium Channels,TWIK-related spinal cord K+ channel (TRESK), which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNK18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tandem pore domain potassium channels | KCNK13B,DDX1,KCNK4,KCNK6,KCNK1A,KCNK2B,KCNK3A,KCNK2,KCNK13A,KCNK10B |
| Potassium Channels | KCNK3A,KCNK13B,KCNS3,KCNG1,KCNJ1A.4,KCNA2,KCNF1,KCNH5,KCNG4A,KCNJ1A.2 |
| Neuronal System | CHRNB4,SLC1A3B,KCNJ1A.1,SYN2,UNC13B,KCNA6,KCNAB2,RAB3AB,KCNK4,CHRNA7 |
Protein Function
KCNK18 has several biochemical functions, for example, calcium-activated potassium channel activity,outward rectifier potassium channel activity,potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNK18 itself. We selected most functions KCNK18 had, and list some proteins which have the same functions with KCNK18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| potassium ion leak channel activity | KCNK5,KCNK3A,TMEM175,KCNK2,KCNK5A,KCNK10B,KCNK1A,KCNK4,DDX1,KCNK1 |
| outward rectifier potassium channel activity | REST,KCNA5,KCNB1,KCNK2,KCNK1A,KCNK2B,KCNQ1,KCNK5B |
| potassium channel activity | KCNK1B,KCNK3A,DDX1,KCNQ2A,KCNK15,KCNC1A,KCNK9,KCNG4A,ABCC9,KCNC4 |
| calcium-activated potassium channel activity | KCNMB2,KCNN2,KCNMA1A,KCNN1A,KCNMB3,KCNMB1,CCT8L2,KCNMA1,KCNN4,KCNN1 |
Interacting Protein
KCNK18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNK18 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNK18.
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References
- Sehgal, SA; Hassan, M; et al. Pharmacoinformatics elucidation of potential drug targets against migraine to target ion channel protein KCNK18. DRUG DESIGN DEVELOPMENT AND THERAPY 8:571-581(2014).
- Ramirez, A; Hinojosa, LM; et al. KCNH1 potassium channels are expressed in cervical cytologies from pregnant patients and are regulated by progesterone. REPRODUCTION 146:615-623(2013).
