KCNK1
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Official Full Name
potassium channel, subfamily K, member 1 -
Overview
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. -
Synonyms
KCNK1;potassium channel, subfamily K, member 1;potassium channel subfamily K member 1;inward rectifying potassium channel protein TWIK-1;TWIK-1;AI788889
Recombinant Proteins
- Human
- Rat
- Mouse
- Guinea pig
- Pongo Abelii
- Oryctolagus cuniculus (Rabbit)
- Mus musculus
- Bovine
- Wheat Germ
- Mammalian Cells
- HEK293
- E.coli
- Non
- His
- DDK
- Myc
- Avi
- Fc
Involved Pathway
KCNK1 involved in several pathways and played different roles in them. We selected most pathways KCNK1 participated on our site, such as Neuronal System,Potassium Channels,Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK), which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuronal System | KCND1,KCNJ1A.5,ARL6IP5A,RERG,KCNJ1A.3,SYT1A,KCNN1,KCNA1,SLC1A2B,CACFD1 |
| Potassium Channels | KCNC4,KCND2,KCNAB1A,KCNG1,KCNQ1,KCNJ1,KCNK3A,KCNAB2,KCNK18,KCNH2A |
| Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) | KCNK1B,KCNK1A,KCNK7,KCNK6 |
| Tandem pore domain potassium channels | KCNK13A,KCNK4,KCNK6,KCNK16,KCNK10B,KCNK18,KCNK2,KCNK7,KCNK3A,KCNK1B |
Protein Function
KCNK1 has several biochemical functions, for example, inward rectifier potassium channel activity,potassium channel activity,potassium ion leak channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNK1 itself. We selected most functions KCNK1 had, and list some proteins which have the same functions with KCNK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inward rectifier potassium channel activity | KCNJ1B,KCNJ2A,KCNJ8,KCNJ1A.3,KCNJ11L,KCNJ14,KCNJ13,KCNJ1A.2,KCNH2,KCNJ1 |
| potassium channel activity | KCNC1A,KCNK1B,TRPM5,KCNK5,KCNK5B,KCNK13B,KCNG1,KCNK2B,KCNQ2A,KCNK13A |
| potassium ion leak channel activity | KCNK5B,KCNK6,KCNK7,KCNK10,KCNK5A,KCNK9,KCNK1B,KCNK13A,KCNK5,DDX1 |
| NOT voltage-gated potassium channel activity | KCNQ1 |
| sodium channel activity | TRPM5,SCN12AB,ACCN4,SCN1LAB,SCN4AB,ASIC1C,PKD2L1,SLC4A11,ASIC4B,ACCN3 |
Interacting Protein
KCNK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNK1.
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References
- Lin, W; Burks, CA; et al. Taste receptor cells express pH-sensitive leak K+ channels. JOURNAL OF NEUROPHYSIOLOGY 92:2909-2919(2004).
