KCNC4
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Official Full Name
potassium voltage-gated channel, Shaw-related subfamily, member 4 -
Overview
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. -
Synonyms
KCNC4;potassium voltage-gated channel, Shaw-related subfamily, member 4;C1orf30, chromosome 1 open reading frame 30;potassium voltage-gated channel subfamily C member 4;HKSHIIIC;Kv3.4;K+ channel subunit;voltage-gated potassium channel subunit KV3.
Recombinant Proteins
- Rat
- Zebrafish
- Mouse
- Human
- Mus musculus
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
Involved Pathway
KCNC4 involved in several pathways and played different roles in them. We selected most pathways KCNC4 participated on our site, such as Neuronal System,Potassium Channels,Voltage gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Potassium Channels | KCNK10B,KCNK3A,KCNV1,KCND1,KCNMA1,KCNS2,KCNK2B,KCNH1B,KCNS3A,KCNS3 |
| Neuronal System | KCNA10,KCNH8,SLC1A3A,CPLX2L,GNGT2B,LIN7B,KCNF1,PANX1A,KCNA7,SLC6A11 |
| Voltage gated Potassium channels | KCNAB2B,KCNH1A,KCNF1A,KCNA7,KCNH5A,KCNH6A,KCNA2B,KCNAB2,KCNQ2,KCNAB1A |
Protein Function
KCNC4 has several biochemical functions, for example, delayed rectifier potassium channel activity,potassium channel activity,voltage-gated potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNC4 itself. We selected most functions KCNC4 had, and list some proteins which have the same functions with KCNC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| voltage-gated potassium channel activity | KCNS3A,KCNA6,KCNH2A,KCNC1,KCNMA1A,CNGA3,KCNA4,HCN4,HTR3A,KCNS3B |
| potassium channel activity | KCNG1,DDX1,KCNK1B,KCNK1A,TMEM38B,KCNK3,KCNK4,KCNK10,KCNA2B,KCNC3A |
| delayed rectifier potassium channel activity | KCNS2,KCNF1A,KCNA7,KCND1,KCNV2,KCNG2,KCNF1,KCNV2B,KCNA2B,KCNA2 |
Interacting Protein
KCNC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNC4.
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References
- VEH, RW; LICHTINGHAGEN, R; et al. IMMUNOHISTOCHEMICAL LOCALIZATION OF 5 MEMBERS OF THE KV1 CHANNEL SUBUNITS - CONTRASTING SUBCELLULAR LOCATIONS AND NEURON-SPECIFIC CO-LOCALIZATIONS IN RAT-BRAIN. EUROPEAN JOURNAL OF NEUROSCIENCE 7:2189-2205(1995).
