KCNA10
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Official Full Name
potassium voltage-gated channel, shaker-related subfamily, member 10 -
Overview
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. -
Synonyms
KCNA10;potassium voltage-gated channel, shaker-related subfamily, member 10;potassium voltage-gated channel subfamily A member 10;Kv1.8;cyclic GMP gated potassium channel;voltage-gated potassium channel subunit Kv1.8;Kcn1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KCNA10-228H | Recombinant Human KCNA10, GST-tagged | E.coli | Human | GST | 1-216aa | |
| KCNA10-6032C | Recombinant Chicken KCNA10 | Mammalian Cells | Chicken | His |
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| KCNA10-5078HCL | Recombinant Human KCNA10 293 Cell Lysate | HEK293 | Human | Non |
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| RFL2429HF | Recombinant Full Length Human Potassium Voltage-Gated Channel Subfamily A Member 10(Kcna10) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length (1-511) |
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| RFL9622GF | Recombinant Full Length Chicken Potassium Voltage-Gated Channel Subfamily A Member 10(Kcna10) Protein, His-Tagged | E.coli | Chicken | His | Full L. Full Length (1-516) |
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Involved Pathway
KCNA10 involved in several pathways and played different roles in them. We selected most pathways KCNA10 participated on our site, such as Neuronal System,Potassium Channels,Voltage gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNA10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Voltage gated Potassium channels | KCNH2,KCNH1A,KCNA4,KCNA7,KCNA1,KCNAB1,KCNC3A,KCNB2,KCNH5A,KCNA6 |
| Neuronal System | KCNN3,KCNJ14,SLC6A1A,CHRNA4,STXBP1A,KCND3,KCNH2A,KCNN1B,PPFIA1,CHRNA1 |
| Potassium Channels | KCNF1A,KCNC1A,KCNG4A,KCNC1B,KCNH5A,KCNH1,HCN4,KCNAB1A,KCNV1,KCNQ3 |
Protein Function
KCNA10 has several biochemical functions, for example, delayed rectifier potassium channel activity,intracellular cyclic nucleotide activated cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNA10 itself. We selected most functions KCNA10 had, and list some proteins which have the same functions with KCNA10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| intracellular cyclic nucleotide activated cation channel activity | CNGA4 |
| delayed rectifier potassium channel activity | KCNF1,KCNS3,KCNQ2,KCNQ4,KCNF1A,KCNC2,KCNC1B,KCNV2,KCNC4,KCNV2B |
Interacting Protein
KCNA10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNA10 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNA10.
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References
- Piwowarski, T; Panofen, F; et al. Molecular cloning and partial functional characterization of Tsha3 - a novel modulatory potassium channel alpha-subunit of trout CNS. MOLECULAR BRAIN RESEARCH 124:124-133(2004).
- Yao, XQ; Tian, SL; et al. Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 13:2831-2839(2002).
