KAT6A
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Official Full Name
K(lysine) acetyltransferase 6A -
Overview
MYST histone acetyltransferase (monocytic leukemia) 3, also known as MYST3, is an enzyme that, in humans, is encoded by the MYST3 gene. -
Synonyms
KAT6A;K(lysine) acetyltransferase 6A;RUNXBP2;MOZ;Monocytic leukemia zinc finger protein;ZNF220;MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3;KAT6A;EC 2.3.1.48;runt-related transcription factor binding protein 2;MGC167033;Runt-related transcription factor-binding protein 2;Zinc finger protein 220;EC 3.1.26.4;MYST3;histone acetyltransferase MYST3;MYST-3;OTTHUMP00000197392;OTTHUMP00000197394;OTTHUMP00000225722;MYST histone acetyltransferase (monocytic leukemia) 3
Recombinant Proteins
- Rat
- Zebrafish
- Human
- Mammalian Cells
- Insect Cells
- HEK293
- E.coli
- Wheat Germ
- His
- Flag
- Avi
- Fc
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KAT6A-3156R | Recombinant Rat KAT6A Protein | Mammalian Cells | Rat | His |
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| KAT6A-6689Z | Recombinant Zebrafish KAT6A | Mammalian Cells | Zebrafish | His |
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| KAT6A-12H | Recombinant Human KAT6A Protein (488-778), N-hFc tagged | Insect Cells | Human | Flag | 488-778 |
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| KAT6A-2812R | Recombinant Rat KAT6A Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| KAT6A-2812R-B | Recombinant Rat KAT6A Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| KAT6A-3219H | Recombinant Human KAT6A protein, GST-tagged | E.coli | Human | GST | 420-510 aa |
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| KAT6A-5866H | Recombinant Human KAT6A Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
KAT6A involved in several pathways and played different roles in them. We selected most pathways KAT6A participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KAT6A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | KDM4D,ELP2,SUZ12,KDM4C,ATXN7L3,KDM6B,KDM2B,C17orf81,KDM7AB,ACTL6A |
| Chromatin organization | SAP30L,SMARCC2,PBRM1,ANO9A,PHF17,ING5,TADA2B,ARID5B,SUZ12A,ARID1A |
| HATs acetylate histones | EPC1,ING5B,KIAA1267,MBIP,KAT7A,KAT8,KANSL3,EP400,ZZZ3,KAT7B |
Protein Function
KAT6A has several biochemical functions, for example, DNA binding,histone acetyltransferase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KAT6A itself. We selected most functions KAT6A had, and list some proteins which have the same functions with KAT6A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | RNF144A,ZSWIM1,ZNF622,ZFAND2A,ZDHHC24,RNF183,CLIP1,ZNF75D,ZDHHC8B,MUL1 |
| transferase activity | TAMM41,MGST1.1,UGT5B4,SULT1ST7,HS3ST3B1A,EPHA2A,DNMT3,UGT1A5,MGAT4C,GM4952 |
| transcription coactivator activity | TAF7,JUNB,HSF2,SP4,BIRC2,SMARCC2,EP300,CD3D,Ankar,JUNBA |
| DNA binding | TFAP2B,MYCLA,FOXI3B,SCMH1,POU5F2,ETV5,RBPJ,ZBED3,TAF4B,NUCB2 |
| histone acetyltransferase activity | TAF1,ATF2,MGEA5,TAF1L,KAT5,CREBBP,KAT2B,KAT8,vnc,METTL8 |
| transferase activity, transferring acyl groups other than amino-acyl groups | SCP2A,ACAA1A,KAT7B,MOGAT3A,ELOVL6,HTATIP,KAT7A,DGAT2L6 |
| metal ion binding | ACAP3B,ZNF692,MCM10,ZFP704,ZNF207A,GEN1,NAALAD2,ZFYVE26,ZNF264,SIAH2L |
Interacting Protein
KAT6A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KAT6A here. Most of them are supplied by our site. Hope this information will be useful for your research of KAT6A.
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References
- Arboleda, VA; Lee, H; et al. De Novo Nonsense Mutations in KAT6A, a Lysine Acetyl-Transferase Gene, Cause a Syndrome Including Microcephaly and Global Developmental Delay. AMERICAN JOURNAL OF HUMAN GENETICS 96:498-506(2015).
- Tham, E; Lindstrand, A; et al. Dominant Mutations in KAT6A Cause Intellectual Disability with Recognizable Syndromic Features. AMERICAN JOURNAL OF HUMAN GENETICS 96:507-513(2015).
