KARS
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Official Full Name
lysyl-tRNA synthetase -
Overview
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
KARS;lysyl-tRNA synthetase;lysine--tRNA ligase;KARS2;lysine tRNA ligase;lysRS;KRS;CMTRIB;KIAA0070
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KARS-1010H | Recombinant Human KARS, His-tagged | E.coli | Human | His |
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| KARS-2296C | Recombinant Chicken KARS | Mammalian Cells | Chicken | His |
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| KARS-2338R | Recombinant Rhesus monkey KARS Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| KARS-29008TH | Recombinant Human KARS, His-tagged | E.coli | Human | His | 535 amino acids |
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| KARS-527Z | Recombinant Zebrafish KARS | Mammalian Cells | Zebrafish | His |
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| KARS-8215H | Recombinant Human KARS protein, His & T7-tagged | E.coli | Human | His&T7 | Arg323~Arg553 |
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| KARS-5090HCL | Recombinant Human KARS 293 Cell Lysate | HEK293 | Human | Non |
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| KARS-2159R | Recombinant Rhesus Macaque KARS Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| KARS-2159R-B | Recombinant Rhesus Macaque KARS Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| Kars-3642M | Recombinant Mouse Kars Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| KARS-6605H | Recombinant Human KARS Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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Involved Pathway
KARS involved in several pathways and played different roles in them. We selected most pathways KARS participated on our site, such as Aminoacyl-tRNA biosynthesis,Cytosolic tRNA aminoacylation,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with KARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | NR1D2A,TBX5,RARGA,EIF4H,CHST13,ZNF558,ZNF302,AIMP2,AIMP1,CSTF1 |
| Cytosolic tRNA aminoacylation | FARSB,EEF1E1,AIMP2,AIMP1,MADD,DARS,AARS |
| Mitochondrial tRNA aminoacylation | WARS2,FARS2,EARS2 |
| Aminoacyl-tRNA biosynthesis | MARS2,FARSB,YARS,DARS,TARS2,LARS,MTFMT,FARS2,VARS2,SARS2 |
| tRNA Aminoacylation | FARSB,WARS2,EARS2,AARS,AIMP2,FARS2,AIMP1,EEF1E1,DARS,MADD |
Protein Function
KARS has several biochemical functions, for example, ATP binding,amino acid binding,lysine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KARS itself. We selected most functions KARS had, and list some proteins which have the same functions with KARS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tRNA binding | YARS,ALKBH8,FARS2,THG1L,AIMP1,TERT,AARS,IFIT5,FDXACB1,PTCD1 |
| metal ion binding | SPATA21,RIOK1,ZEB1B,IKZF4,PRDM5,CYP2P7,JADE3,FURIN,NRP1,CYP2AA8 |
| amino acid binding | TPH1A,AARS2,TH,DPYS,AARS,DDAH2,TPH2,TPH1,SHMT2,DDAH1 |
| protein binding | CRX,DCAF7,ZFYVE20,EPHA7,SRM,PC,RAD51,CDKL3,TEAD2,AMELX |
| ATP binding | CLK3,PIP5K1A,ABCG2,HSPA8,MAPK12A,ATP2A2B,UCKL1A,CSNK1G2B,MAPK8B,PIP5K2 |
Interacting Protein
KARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KARS here. Most of them are supplied by our site. Hope this information will be useful for your research of KARS.
AIMP2;RPSA;gag;LAMB1;EPRS;IKBKE;TANK;FRS3;DYSF;GAPDH
Resources
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References
- Hause, RJ; Stark, AL; et al. Identification and Validation of Genetic Variants that Influence Transcription Factor and Cell Signaling Protein Levels. AMERICAN JOURNAL OF HUMAN GENETICS 95:194-208(2014).
- Ergunay, K; Gunay, F; et al. Serological, Molecular and Entomological Surveillance Demonstrates Widespread Circulation of West Nile Virus in Turkey. PLOS NEGLECTED TROPICAL DISEASES 8:-(2014).
