JUND

  • Official Full Name

    jun D proto-oncogene

  • Overview

    The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]

  • Synonyms

    JUND;jun D proto-oncogene;AP-1;transcription factor jun-D;JunD-FL isoform;activator protein 1

Recombinant Proteins

  • Human
  • Rat
  • Zebrafish
  • Mouse
  • Mammalian Cells
  • HEK293
  • His
  • Avi&Fc&His
  • DDK&Myc
  • Flag

    Involved Pathway

    JUND involved in several pathways and played different roles in them. We selected most pathways JUND participated on our site, such as ATF-2 transcription factor network,AhR pathway,Corticotropin-releasing hormone, which may be useful for your reference. Also, other proteins which involved in the same pathway with JUND were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ATF-2 transcription factor network JDP2,RUVBL2,DDIT3,DUSP1,KCNA3,JUN,DUSP10,KAT5,DUSP5,CDK4
    Oncostatin M Signaling Pathway CYR61
    AhR pathway AHRR,NQO1,CDKN1A,CDKN1B,CYP1B1,CYP1A1,FLG,CDC37,PTGES3,AIP
    Integrated Pancreatic Cancer Pathway TOP2A,CD82,MST1,TOP1,PPP1R13L,CASP12,MAPK4,WRN,AGA,CST3
    EGFR1 Signaling Pathway SH3BGRL,EPPK1,KLF11,ARF4,APPL2,RGS16,TNK2,CEACAM1,USP6NL,DNM1
    Corticotropin-releasing hormone TFAP2A,PARP1,CYP11B1,JUNB,TBX19,CASP12,ADRBK2,CYP11A1,KRT1,CRHR2
    MAPK signaling pathway HSPA2,MAPK12B,SRF,NTRK2,RPS6KA4,ZAK,TAOK1,ARRB2B,SRFA,PRKACB
    Hypertrophy Model CYR61,MSTN,WDR1,IFRD1,DUSP14,MSTNB,ANKRD1,MYOG,ADAM10A,HBEGFB

    Protein Function

    JUND has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JUND itself. We selected most functions JUND had, and list some proteins which have the same functions with JUND. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding THRB,IL6R,USF1,KAT8,RAD9A,AXIN2,YWHAB,RPS19BP1,HDAC3,BCR
    transcription factor binding PER1,CSNK2B,CREBBP,NKX2,STK4,FOXF2,BPTF,ARNT,RBFOX2,MYC
    transcription coactivator activity Ankar,KAT6A,DYRK1B,YAF2,APEX1,RIPK3,MED14,MED23,TFDP1A,NEUROG3
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GRHL1,SIX2,DLX4,CC2D1A,NKX6-2,RBPJ,GATA4,ZNF680,ZNF92,SRF
    transcription regulatory region DNA binding ATF3,MEF2C,SALL3B,SREBF1,HOXA13,TBL1X,TA,TP53,FOXA3,CDK9
    ligand-dependent nuclear receptor binding NCOA3,TADA3,NCOA2,ISL1,NCOR2,NCOR1,UBA3,SLC30A9,ARID1A,SRA1
    protein binding ADRBK1,SIT1,RNF149,GREM1,S100A2,OSBP,GPSM3,RASAL2,ARFGAP1,COG4
    RNA polymerase II transcription factor activity, sequence-specific DNA binding NFIB,HIF1AL2,SOX8A,FOXI3A,FOXO1,SP2,TFAP2D,LMO2,JUN,SPI1A

    Interacting Protein

    JUND has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JUND here. Most of them are supplied by our site. Hope this information will be useful for your research of JUND.

    FOS;q7lyy4_9dela;FOSL2;ACTR3;MDM2;AR

    Resources

    Research Area

    Apoptosis Transcription Factors and Regulators
    Cancer Stem Cell Transcription Factors
    Wnt Intracellular Signaling
    C-type Lectin Receptors
    NOD-like Receptors and the Inflammasome

    References

    • Matsumura, H; Ogata, Y; et al. Melatonin regulates human bone sialoprotein gene transcription. JOURNAL OF ORAL SCIENCE 56:67-76(2014).
    • Zhou, LM; Matsumura, H; et al. Protamine stimulates bone sialoprotein gene expression. GENE 516:228-237(2013).

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