JAG2

  • Official Full Name

    jagged 2

  • Overview

    The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    JAG2;jagged 2;protein jagged-2;HJ2;SER2

Recombinant Proteins

  • Human
  • Mouse
  • CHO
  • Mammalian cells
  • Wheat Germ
  • HEK293
  • Mammalian Cell
  • E.coli
  • Fc
  • Non
  • His
  • His&T7
  • His&Fc&Avi
  • His&GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
JAG2-229H Active Recombinant Human JAG2, Fc Chimera CHO Human Fc
Jag2-5666M Active Recombinant Mouse Jagged 2, Fc-tagged Mammalian cells Mouse Fc 27-1084 a.a.
JAG2-29877TH Recombinant Human JAG2 Wheat Germ Human Non 90 amino acids
JAG2-382H Recombinant Human JAG2, Fc-tagged HEK293 Human Fc 1-1054 a.a.
Jag2-383M Recombinant Mouse Jag2, Fc-tagged HEK293 Mouse Fc 24-1082 a.a.
JAG2-601H Recombinant Human JAG2 Mammalian Cell Human His
JAG2-8407M Recombinant Mouse JAG2 Protein Mammalian Cell Mouse His
JAG2-1869H Recombinant Human JAG2 protein, His-tagged E.coli Human His Phe714~His981
Jag2-1870M Recombinant Mouse Jag2 protein, His & T7-tagged E.coli Mouse His&T7 Cys709~Pro941
JAG2-3182H Recombinant Human JAG2 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
JAG2-3182H-B Recombinant Human JAG2 Protein Pre-coupled Magnetic Beads HEK293 Human
JAG2-3397H Recombinant Human JAG2 protein, His-GST-tagged E.coli Human His&GST Phe714~His981
Jag2-79M Recombinant Mouse Jag2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
Jag2-79M-B Recombinant Mouse Jag2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    JAG2 involved in several pathways and played different roles in them. We selected most pathways JAG2 participated on our site, such as Activated NOTCH1 Transmits Signal to the Nucleus,Constitutive Signaling by NOTCH1 HD Domain Mutants,Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Constitutive Signaling by NOTCH1 t(7 JAG1
    9)(NOTCH1:M1580_K2555) Translocation Mutant JAG1
    Constitutive Signaling by NOTCH1 PEST Domain Mutants CDK8,HEY2,HEYL,CCNC,JAG1,HDAC5,HDAC6,HEY1,MIB1,ADAM10
    Activated NOTCH1 Transmits Signal to the Nucleus DNER,DTX2,JAG1,DLK1,CNTN1,MIB1,ADAM10
    Delta-Notch Signaling Pathway SAP30,TCF3B,RING1,CNTFR,HIVEP3,TUBB3,HES6,YY1,ADAM10A,APPA
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants JAG1,CDK8,MIB1,CCNC,HDAC5,ADAM10,HDAC6,HEYL,HEY2,HEY1
    Constitutive Signaling by NOTCH1 HD Domain Mutants ADAM10,MIB1,JAG1
    Diseases of signal transduction STRA6,RBP1,RBP4,TRIM24,OPN1MW2,RLBP1,KREMEN1,CUX1,CCNC,OPN1MW
    Disease GCKR,KPNA5,CTDP1,NPM1,RDBP,FDXR,VPS37A,LRRFIP1,SFTPB,DOCK2

    Protein Function

    JAG2 has several biochemical functions, for example, Notch binding,calcium ion binding,growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by JAG2 itself. We selected most functions JAG2 had, and list some proteins which have the same functions with JAG2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding C1QTNF6,ARHGEF1,GRHL2,KIAA1967,RFX6,CYSLTR2,NT5C2,XIRP2,SREBF1,2610109H07Rik
    growth factor activity TGFB3,PDGFAA,AREG,FGF20,REG1A,TYMP,GFER,CTGF,MSTNB,NDP
    calcium ion binding CAMKK2,CDH1,MMP19,CD93,SYT12,EHD3,ATP2A2,SULF2B,CHP,CAPN13
    Notch binding NOTCH4,DLL1,JAG1,HIF1AN,GALNT11,DNER,EGFL7,AAK1,NCOR2,NOV

    Interacting Protein

    JAG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAG2.

    GFI1B;CACNA1A;ATXN7;ATN1;thrS2;q81wx2_bacan;q9wmx2-pro_0000037548

    Resources

    Research Area

    Notch Family
    EMT Induction

    References

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